188686

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1997686..1998520 Replicon chromosome
Accession NZ_CP068827
Organism Escherichia coli strain RIVM_C030371

Toxin (Protein)


Gene name yeeV Uniprot ID S1PLF5
Locus tag JNN58_RS09535 Protein ID WP_000854690.1
Coordinates 1998143..1998520 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1P7N8
Locus tag JNN58_RS09530 Protein ID WP_001305076.1
Coordinates 1997686..1998054 (+) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN58_RS09490 1992769..1993896 + 1128 Protein_1860 hypothetical protein -
JNN58_RS09495 1993972..1994427 + 456 WP_000581502.1 hypothetical protein -
JNN58_RS09500 1994506..1994739 + 234 WP_001119729.1 DUF905 family protein -
JNN58_RS09505 1994839..1995657 + 819 WP_001234628.1 DUF945 domain-containing protein -
JNN58_RS09510 1995712..1996197 + 486 WP_000849565.1 antirestriction protein -
JNN58_RS09515 1996213..1996689 + 477 WP_001186726.1 RadC family protein -
JNN58_RS09520 1996752..1996973 + 222 WP_000692329.1 DUF987 domain-containing protein -
JNN58_RS09525 1996992..1997636 + 645 WP_000094916.1 hypothetical protein -
JNN58_RS09530 1997686..1998054 + 369 WP_001305076.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JNN58_RS09535 1998143..1998520 + 378 WP_000854690.1 TA system toxin CbtA family protein Toxin
JNN58_RS09540 1998517..1999005 + 489 WP_000761699.1 hypothetical protein -
JNN58_RS09545 1999022..1999219 + 198 WP_000839293.1 DUF957 domain-containing protein -
JNN58_RS09550 1999304..2000149 + 846 WP_001529401.1 DUF4942 domain-containing protein -
JNN58_RS09555 2000218..2000613 + 396 WP_000208382.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein -
JNN58_RS09560 2000606..2001539 + 934 Protein_1874 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
JNN58_RS09565 2001971..2002126 + 156 WP_000729638.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2001971..2002126 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 14057.04 Da        Isoelectric Point: 9.1510

>T188686 WP_000854690.1 NZ_CP068827:1998143-1998520 [Escherichia coli]
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYAQVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T188686 NZ_CP090535:206805-207290 [Salmonella enterica]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13560.39 Da        Isoelectric Point: 4.7830

>AT188686 WP_001305076.1 NZ_CP068827:1997686-1998054 [Escherichia coli]
MSDTLPGTTLPDDNKDLPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHPDQAFPLLMKQPELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCDYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT188686 NZ_CP090535:206530-206817 [Salmonella enterica]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB S1PLF5


Antitoxin

Source ID Structure
AlphaFold DB S1P7N8

References