Detailed information of TA system TA188661

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4446571..4447391
• Replicon: chromosome
• Accession: NZ_CP068826
• Organism: Escherichia coli strain RIVM_C030300

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: A0A0V9MKL8
• Locus tag: JNN53_RS21375
• Protein ID: WP_001550554.1
• Coordinates: 4446571..4446828 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: JNN53_RS21380
• Protein ID: WP_001519303.1
• Coordinates: 4446840..4447391 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JNN53_RS21355	4441857..4442963	+	1107	WP_001519308.1	N-acetylneuraminate epimerase	-
JNN53_RS21360	4443028..4444008	+	981	WP_001519307.1	transposase	-
JNN53_RS21365	4444591..4445832	-	1242	Protein_4184	helicase YjhR	-
JNN53_RS21370	4445895..4446194	+	300	WP_001519304.1	GNAT family N-acetyltransferase	-
JNN53_RS21375	4446571..4446828	+	258	WP_001550554.1	hypothetical protein	Toxin
JNN53_RS21380	4446840..4447391	+	552	WP_001519303.1	N-acetyltransferase	Antitoxin
JNN53_RS21385	4447443..4447604	+	162	WP_001519302.1	hypothetical protein	-
JNN53_RS21390	4447641..4448189	+	549	WP_001519301.1	hypothetical protein	-
JNN53_RS21395	4448316..4448576	+	261	WP_000084876.1	hypothetical protein	-
JNN53_RS21400	4448614..4448730	+	117	Protein_4191	VOC family protein	-
JNN53_RS21405	4448975..4450096	+	1122	WP_000010833.1	M42 family metallopeptidase	-
JNN53_RS21410	4450093..4450371	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
JNN53_RS21415	4450383..4451696	+	1314	WP_001519300.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9744.33 Da
• Isoelectric Point: 11.0090

>T188661 WP_001550554.1 NZ_CP068826:4446571-4446828 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKPVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T188661 NZ_CP090529:3535381-3535599 [Salmonella enterica]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20463.61 Da
• Isoelectric Point: 6.8758

>AT188661 WP_001519303.1 NZ_CP068826:4446840-4447391 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT188661 NZ_CP090529:3534979-3535353 [Salmonella enterica]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA

Structures

Toxin

• AlphaFold DB: A0A0V9MKL8