Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4744549..4745347 Replicon chromosome
Accession NZ_CP068824
Organism Escherichia coli strain RIVM_C030197

Toxin (Protein)


Gene name yeeV Uniprot ID U9XMP3
Locus tag JNN63_RS22890 Protein ID WP_000854735.1
Coordinates 4744970..4745347 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A067H947
Locus tag JNN63_RS22885 Protein ID WP_001285415.1
Coordinates 4744549..4744923 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN63_RS22850 4740305..4741189 + 885 WP_024166630.1 50S ribosome-binding GTPase -
JNN63_RS22855 4741308..4741985 + 678 WP_120136232.1 hypothetical protein -
JNN63_RS22860 4741991..4742224 + 234 WP_001278287.1 DUF905 family protein -
JNN63_RS22865 4742314..4743132 + 819 WP_063714298.1 DUF945 domain-containing protein -
JNN63_RS22870 4743214..4743693 + 480 WP_120136233.1 antirestriction protein -
JNN63_RS22875 4743709..4744185 + 477 WP_001366855.1 RadC family protein -
JNN63_RS22880 4744248..4744469 + 222 WP_000692309.1 DUF987 domain-containing protein -
JNN63_RS22885 4744549..4744923 + 375 WP_001285415.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JNN63_RS22890 4744970..4745347 + 378 WP_000854735.1 TA system toxin CbtA family protein Toxin
JNN63_RS22895 4745344..4745832 + 489 WP_000761677.1 hypothetical protein -
JNN63_RS22900 4745844..4746041 + 198 WP_000839291.1 DUF957 domain-containing protein -
JNN63_RS22905 4746126..4746992 + 867 WP_001280433.1 DUF4942 domain-containing protein -
JNN63_RS22910 4747064..4747327 + 264 WP_025492088.1 type II toxin-antitoxin system ParD family antitoxin -
JNN63_RS22915 4747324..4747650 + 327 WP_000779483.1 type II toxin-antitoxin system RelE/ParE family toxin -
JNN63_RS22920 4748533..4750071 + 1539 WP_001187178.1 lysine decarboxylation/transport transcriptional activator CadC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4727954..4757884 29930


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14061.07 Da        Isoelectric Point: 8.2904

>T188603 WP_000854735.1 NZ_CP068824:4744970-4745347 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T188603 NZ_CP090511:1901577-1901885 [Xylella fastidiosa subsp. multiplex]
GTGACCATCACAAAGAAAATCAATGTCTCCGAACTGCCAGAGTTCGATGCCGCCGAATACCTGAACAGCGAAGAGGAGGT
AGCCGCGTATCTCACGGCTGTTCTTGAAGAAAACGATCCAGCACTGTTAGCGGCTGCGCTGGGTGACATTGCCCGTTCAC
GTGGTATGTCTCAGATTGCGAAGGATTCTGGCATCACGCGGGAAGCTCTATACAAGGCTCTTCGGCCTGGCAGTGAACCA
CGCTTCGATACGATAAGCCGCGTCTGTACCGCCCTAGGTATACGTCTAGTAGCGCAACCAATGCATTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13663.32 Da        Isoelectric Point: 5.8640

>AT188603 WP_001285415.1 NZ_CP068824:4744549-4744923 [Escherichia coli]
VSDTHPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT188603 NZ_CP090511:1901274-1901573 [Xylella fastidiosa subsp. multiplex]
ATGACCTACACGGTAAAACGACTTGAAGGGTTCTCTGACTGGCTAAAGGGCCTAAAGGATGGGCTGGCAAGGCAGCGCCT
CATCAAGCGCTTACGCAAGGTGCAGCTCGGCAACTTTGGAGACGTGCAGCCAGTGGGTGAAGGCGTGTTTGAAATGCGCG
AACACTTCGGACCTGGCTGGCGTATGTACTACGTGCAGCGAGGCAGCTTTCTCATCGTGATGCTCGGCGGCGGCGACAAG
TCAACGCAGCAATCAGACATTCGTCGGACCATTGAGCTAGCAAAATCTTTAGAGGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XMP3

Antitoxin

Source ID Structure
AlphaFold DB A0A067H947

References