Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4553773..4554295 Replicon chromosome
Accession NZ_CP068824
Organism Escherichia coli strain RIVM_C030197

Toxin (Protein)


Gene name relE Uniprot ID A0A829L6G8
Locus tag JNN63_RS21900 Protein ID WP_001105433.1
Coordinates 4553773..4554063 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SC69
Locus tag JNN63_RS21905 Protein ID WP_000212715.1
Coordinates 4554053..4554295 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN63_RS21885 4548941..4550596 + 1656 WP_001550509.1 alpha,alpha-phosphotrehalase -
JNN63_RS21890 4550990..4553128 + 2139 WP_000187798.1 anaerobic ribonucleoside-triphosphate reductase -
JNN63_RS21895 4553308..4553772 + 465 WP_001009182.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JNN63_RS21900 4553773..4554063 - 291 WP_001105433.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JNN63_RS21905 4554053..4554295 - 243 WP_000212715.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JNN63_RS21910 4554487..4554873 - 387 WP_001232246.1 cytochrome b562 -
JNN63_RS21915 4555056..4556408 - 1353 WP_001162173.1 metalloprotease PmbA -
JNN63_RS21920 4556502..4557053 + 552 WP_000166270.1 ribosome-associated protein -
JNN63_RS21925 4557203..4558576 - 1374 WP_001522402.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11367.23 Da        Isoelectric Point: 10.0238

>T188601 WP_001105433.1 NZ_CP068824:c4554063-4553773 [Escherichia coli]
MNYELAFDPRALKEWQKLGVTVREQFKKKLEDVLKRPRNPSAKLRDLPDCYKIKLRTQGYRLVYQVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

>T188601 NZ_CP090511:1897935-1898228 [Xylella fastidiosa subsp. multiplex]
ATGACCGAGAAACTGACGAGCTACGATCCAGCCGAGGACTTGACCACTGACCAGGCCATCGCCGATTTCATGGCAGCTGC
GTTCGGGACGAACGATCCTGCCTACGTTGCCCACGCGCTGGGCGTCGTTGCCCGCGCCAAGGGCATGACGCAGATCGCCA
GCCAGACAGGGCTATCGCGCGAACAGCTCTACCGCTCGTTCAGTGCCGAAGGCAACCCGACGCTGCGCACGACATTGGCC
GTGATGAAGGCGCTCGGGATCGAGCTGTCTGCGAAACCGTCTGGTGTTCACTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9125.56 Da        Isoelectric Point: 5.1369

>AT188601 WP_000212715.1 NZ_CP068824:c4554295-4554053 [Escherichia coli]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp

>AT188601 NZ_CP090511:1897636-1897932 [Xylella fastidiosa subsp. multiplex]
ATGATTGATTTGAAGCAGACTGACACCTTCCGCAAGTGGCGGGAGAAACTCAAGGATGCGCGCGCCCGCTCAGCCATCGC
CTCGCGCCTCGACCGCTTGGCGTTCGGCCATGTCGGCGACGCGGAGCCAGTAGGGAAAGGTATCAGCGAGCTTCGCATCA
ACTACGGCCCCGGTTACCGGGTGTATTTCCAGCGGCGTGGCGACACGATCTACTTGCTGCTTTGCGGCGGTGACAAAGGA
TCACAAGCGCGCGACATCAAGACTGCGCTGCGCCTGTCTGAACAATGGAGCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829L6G8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H4B3

References