Detailed information of TA system TA188600

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4446616..4447436
• Replicon: chromosome
• Accession: NZ_CP068824
• Organism: Escherichia coli strain RIVM_C030197

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: A0A0V9MKL8
• Locus tag: JNN63_RS21365
• Protein ID: WP_001550554.1
• Coordinates: 4446616..4446873 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: JNN63_RS21370
• Protein ID: WP_001519303.1
• Coordinates: 4446885..4447436 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JNN63_RS21345	4441902..4443008	+	1107	WP_001519308.1	N-acetylneuraminate epimerase	-
JNN63_RS21350	4443073..4444053	+	981	WP_001519307.1	transposase	-
JNN63_RS21355	4444636..4445877	-	1242	Protein_4182	helicase YjhR	-
JNN63_RS21360	4445940..4446239	+	300	WP_001519304.1	GNAT family N-acetyltransferase	-
JNN63_RS21365	4446616..4446873	+	258	WP_001550554.1	hypothetical protein	Toxin
JNN63_RS21370	4446885..4447436	+	552	WP_001519303.1	N-acetyltransferase	Antitoxin
JNN63_RS21375	4447488..4447649	+	162	WP_001519302.1	hypothetical protein	-
JNN63_RS21380	4447686..4448234	+	549	WP_001519301.1	hypothetical protein	-
JNN63_RS21385	4448361..4448621	+	261	WP_000084876.1	hypothetical protein	-
JNN63_RS21390	4448659..4448775	+	117	Protein_4189	VOC family protein	-
JNN63_RS21395	4449020..4450141	+	1122	WP_000010833.1	M42 family metallopeptidase	-
JNN63_RS21400	4450138..4450416	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
JNN63_RS21405	4450428..4451741	+	1314	WP_001519300.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimB	4439100..4447649	8549

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9744.33 Da
• Isoelectric Point: 11.0090

>T188600 WP_001550554.1 NZ_CP068824:4446616-4446873 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKPVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T188600 NZ_CP090511:1897636-1897932 [Xylella fastidiosa subsp. multiplex]
ATGATTGATTTGAAGCAGACTGACACCTTCCGCAAGTGGCGGGAGAAACTCAAGGATGCGCGCGCCCGCTCAGCCATCGC
CTCGCGCCTCGACCGCTTGGCGTTCGGCCATGTCGGCGACGCGGAGCCAGTAGGGAAAGGTATCAGCGAGCTTCGCATCA
ACTACGGCCCCGGTTACCGGGTGTATTTCCAGCGGCGTGGCGACACGATCTACTTGCTGCTTTGCGGCGGTGACAAAGGA
TCACAAGCGCGCGACATCAAGACTGCGCTGCGCCTGTCTGAACAATGGAGCGAATGA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20463.61 Da
• Isoelectric Point: 6.8758

>AT188600 WP_001519303.1 NZ_CP068824:4446885-4447436 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT188600 NZ_CP090511:1897935-1898228 [Xylella fastidiosa subsp. multiplex]
ATGACCGAGAAACTGACGAGCTACGATCCAGCCGAGGACTTGACCACTGACCAGGCCATCGCCGATTTCATGGCAGCTGC
GTTCGGGACGAACGATCCTGCCTACGTTGCCCACGCGCTGGGCGTCGTTGCCCGCGCCAAGGGCATGACGCAGATCGCCA
GCCAGACAGGGCTATCGCGCGAACAGCTCTACCGCTCGTTCAGTGCCGAAGGCAACCCGACGCTGCGCACGACATTGGCC
GTGATGAAGGCGCTCGGGATCGAGCTGTCTGCGAAACCGTCTGGTGTTCACTGA

Structures

Toxin

• AlphaFold DB: A0A0V9MKL8