Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 829735..830570 Replicon chromosome
Accession NZ_CP068824
Organism Escherichia coli strain RIVM_C030197

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0A1A9A5
Locus tag JNN63_RS03925 Protein ID WP_001564063.1
Coordinates 829735..830112 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0K5N986
Locus tag JNN63_RS03930 Protein ID WP_021553056.1
Coordinates 830202..830570 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN63_RS03895 824863..826011 - 1149 WP_000905920.1 capsule polysaccharide export inner-membrane protein KpsE -
JNN63_RS03900 826083..827066 - 984 WP_001296394.1 KpsF/GutQ family sugar-phosphate isomerase -
JNN63_RS03905 827876..828046 - 171 Protein_766 IS110 family transposase -
JNN63_RS03910 828389..829231 - 843 Protein_767 DUF4942 domain-containing protein -
JNN63_RS03915 829316..829510 - 195 WP_024181941.1 DUF957 domain-containing protein -
JNN63_RS03920 829589..829738 - 150 Protein_769 hypothetical protein -
JNN63_RS03925 829735..830112 - 378 WP_001564063.1 TA system toxin CbtA family protein Toxin
JNN63_RS03930 830202..830570 - 369 WP_021553056.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JNN63_RS03935 830733..830954 - 222 WP_000692345.1 DUF987 domain-containing protein -
JNN63_RS03940 831019..831495 - 477 WP_021553055.1 RadC family protein -
JNN63_RS03945 831511..831990 - 480 WP_001564060.1 antirestriction protein -
JNN63_RS03950 832256..833074 - 819 WP_001564059.1 DUF945 domain-containing protein -
JNN63_RS03955 833164..833397 - 234 WP_001278293.1 DUF905 family protein -
JNN63_RS03960 833403..834080 - 678 WP_202852189.1 hypothetical protein -
JNN63_RS03965 834231..834911 - 681 WP_001278649.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - papX 828262..901843 73581


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14094.09 Da        Isoelectric Point: 7.8045

>T188580 WP_001564063.1 NZ_CP068824:c830112-829735 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRSNYRTVNNITRGKHPEAKQ

Download         Length: 378 bp

>T188580 NZ_CP068824:c830112-829735 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGCGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGTACTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCCGGGCAACAGGTCTGATGACCCGCAG
CAACTACAGAACGGTAAATAACATTACCCGGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13615.39 Da        Isoelectric Point: 7.0264

>AT188580 WP_021553056.1 NZ_CP068824:c830570-830202 [Escherichia coli]
VSDTLSGTTHPDDNHDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGNRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT188580 NZ_CP068824:c830570-830202 [Escherichia coli]
GTGTCAGACACACTCTCCGGGACAACGCATCCCGATGACAATCACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTAACAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A1A9A5

Antitoxin

Source ID Structure
AlphaFold DB A0A0K5N986

References