Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 161245..161857 Replicon chromosome
Accession NZ_CP068824
Organism Escherichia coli strain RIVM_C030197

Toxin (Protein)


Gene name hicA Uniprot ID U9YXE2
Locus tag JNN63_RS00690 Protein ID WP_000833473.1
Coordinates 161245..161430 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID L4IWR9
Locus tag JNN63_RS00695 Protein ID WP_000499744.1
Coordinates 161447..161857 (+) Length 137 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN63_RS00680 158086..159237 + 1152 WP_000741501.1 L-threonine dehydrogenase -
JNN63_RS00685 159438..160976 + 1539 WP_001551836.1 aldehyde dehydrogenase AldB -
JNN63_RS00690 161245..161430 + 186 WP_000833473.1 type II toxin-antitoxin system HicA family toxin Toxin
JNN63_RS00695 161447..161857 + 411 WP_000499744.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
JNN63_RS00700 161929..163893 - 1965 WP_001551835.1 glycoside hydrolase family 127 protein -
JNN63_RS00705 163904..165304 - 1401 WP_000204811.1 MFS transporter -
JNN63_RS00710 165530..166345 + 816 WP_000891823.1 AraC family transcriptional regulator -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 62 a.a.        Molecular weight: 6800.89 Da        Isoelectric Point: 11.7053

>T188577 WP_000833473.1 NZ_CP068824:161245-161430 [Escherichia coli]
VKSADVIAILKQHGWEHIRTRGSHHQFRHPVHPGLVTVPHPKKDIKPGTLAQIGRQAGLTF

Download         Length: 186 bp

>T188577 NZ_CP090508:c1454274-1453987 [Xylella fastidiosa subsp. morus]
ATGGCTAAGTCCTATCGACTGACACCGCTGGCCGAGGCCGATCTTGAAGAAATCTGGTTCTACACATTCAGGCACTGGTC
GATAGAGCAGGCCGACAGCTACCACCGTAGCCTAGTTGCAGTTTTCGAGGGGCTGGCAGCAGGTACAAAGCAAGGCTGCC
CTTCTGTTTTGACGGACTTCAATAAATACCTATGTGGTTCGCATGTAGTGTATTTCATGGATTACGCCGATCACTTGGAT
ATTATCCGCATCCTGCATCAGCGGCAGGATACCGAGCGGTACCTATAA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 15241.15 Da        Isoelectric Point: 4.5486

>AT188577 WP_000499744.1 NZ_CP068824:161447-161857 [Escherichia coli]
MFYPAYIHSDPDGSASGFFPDVPGCYFAGDTLDNAFQDARSALVAHFETLCEMNEELPLPGSVETHLVQRAQDFIGGQWL
LVDINMNQFEGRAERINITMPKRLLNKIDTYVRNNPDYANRSAFLAEAARRVLPGV

Download         Length: 411 bp

>AT188577 NZ_CP090508:c1454509-1454267 [Xylella fastidiosa subsp. morus]
ATGAGTCGAAACACATCCGTTGCCCTCGGGCCGCACTTCACCAGCTTTATTGATGCCCAAGTCCAGGGCGGTCGCTACGG
TACCGCCAGCGATGTTGTCAGGGCCGGTCTGCGGCTGCTTGAGGAACACGAAACAAAGGTGAAGGCACTGCAAGATGCGC
TGAATGTTGGCCACCAATCCGGCGAGCCGCGCCCGTTCGACAGCGAGGTGTTTTTGAGCCGGATGCACACGCAGCATGGC
TAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB U9YXE2


Antitoxin

Source ID Structure
AlphaFold DB L4IWR9

References