Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4006886..4007436 Replicon chromosome
Accession NZ_CP068823
Organism Escherichia coli strain RIVM_C029494

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag JNN66_RS18970 Protein ID WP_075861930.1
Coordinates 4006886..4007200 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag JNN66_RS18975 Protein ID WP_075861929.1
Coordinates 4007203..4007436 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN66_RS18945 4002561..4003847 + 1287 WP_000800457.1 peptidylprolyl isomerase SurA -
JNN66_RS18950 4003847..4004836 + 990 WP_075861933.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
JNN66_RS18955 4004833..4005654 + 822 WP_075861932.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
JNN66_RS18960 4005657..4006034 + 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
JNN66_RS18965 4006041..4006889 + 849 WP_075861931.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
JNN66_RS18970 4006886..4007200 - 315 WP_075861930.1 CcdB family protein Toxin
JNN66_RS18975 4007203..4007436 - 234 WP_075861929.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
JNN66_RS18980 4007522..4008001 - 480 WP_000624375.1 type 3 dihydrofolate reductase -
JNN66_RS18985 4008193..4010055 - 1863 WP_000377117.1 glutathione-regulated potassium-efflux system protein KefC -
JNN66_RS18990 4010048..4010578 - 531 WP_000600725.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
JNN66_RS18995 4010686..4012017 - 1332 WP_001183201.1 MFS transporter -
JNN66_RS19000 4012075..4012362 - 288 WP_000203741.1 ferredoxin-like protein FixX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11755.77 Da        Isoelectric Point: 9.0851

>T188570 WP_075861930.1 NZ_CP068823:c4007200-4006886 [Escherichia coli]
MQFTVYRSRGRNAAFPFVIDVTSDIISEINRRIVIPLTPIERFSRIRPPERLNPILLLIDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI

Download         Length: 315 bp

>T188570 NZ_CP090508:503999-504502 [Xylella fastidiosa subsp. morus]
ATGAAATACGCAGGGGATCGTGGTGATCCTTACCTGGACAGCGAAACAGGTGTTCTTCGTAATCTCCTTGGAATCAGGGA
TCAGGGGTGGCTCGATAAAATAGAGTCCACCCTTTCTTTTTTGCGAACCAGCGAATTGCGTGAGCGACCCGTAAAAGGCA
AATTTGATCTAGCGCATTTACAGGAAATCCATAATCGTCTTTTCCAGGATGTGTACGACTGGGCGGGTCAAATCCGTCAA
GTTGAAATCTCGAAAGGCAACACGATGTTTGCCCAGCAGATTGCGATTCAGAGTGCGGCGCAGCAGATCTTTGGGCAGCT
TGCTAAAGAGCGATTTTTGTGTGGCCTTGATGCTGAAGAATTCAGCAAACGGGCAGGTGATTATCTTGGTGAAATTAATG
TACTTCACCCATTCCGCGAGGGAAATGGCAGGACGCAGCGGGAATTCATCGCGCAATTGGCTCAGCGTGCAGGTTACCGG
ATCGACTGGGGCGTGGTCAGCTAG

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8618.59 Da        Isoelectric Point: 5.0789

>AT188570 WP_075861929.1 NZ_CP068823:c4007436-4007203 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAETRWREENTEAIAALNQLADETGCFSDEYRSF

Download         Length: 234 bp

>AT188570 NZ_CP090508:503814-504002 [Xylella fastidiosa subsp. morus]
ATGCTGACAGATCATGAAAAAGCTGAACGCCGTGCTGTGGTGCAAAGCGCACTCGCAAGCCAACGCATTGAGGGGTTAGA
GCCGGATGCGCAAGCCGTTGTTGATGCTGAATGCTGGGCGCGTGGTGAAATGACTATCGCTGCCGCCGTGGACCAGTACA
AAGCGCGTGTTCGGCTCCAGATGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References