Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 72113..72945 Replicon chromosome
Accession NZ_CP068823
Organism Escherichia coli strain RIVM_C029494

Toxin (Protein)


Gene name yeeV Uniprot ID E3PN67
Locus tag JNN66_RS00300 Protein ID WP_000854775.1
Coordinates 72113..72487 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A426P7N5
Locus tag JNN66_RS00305 Protein ID WP_001285645.1
Coordinates 72577..72945 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN66_RS00270 67473..68396 - 924 WP_000535959.1 carboxylate/amino acid/amine transporter -
JNN66_RS00275 68507..69691 - 1185 WP_001172864.1 sugar efflux transporter -
JNN66_RS00280 70075..70221 - 147 WP_001328030.1 hypothetical protein -
JNN66_RS00285 70489..71331 - 843 WP_001274548.1 DUF4942 domain-containing protein -
JNN66_RS00290 71416..71613 - 198 WP_000772035.1 DUF957 domain-containing protein -
JNN66_RS00295 71625..72116 - 492 WP_000976825.1 hypothetical protein -
JNN66_RS00300 72113..72487 - 375 WP_000854775.1 TA system toxin CbtA family protein Toxin
JNN66_RS00305 72577..72945 - 369 WP_001285645.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JNN66_RS00310 73108..73329 - 222 WP_000692303.1 DUF987 domain-containing protein -
JNN66_RS00315 73398..73874 - 477 WP_001318130.1 RadC family protein -
JNN66_RS00320 73890..74375 - 486 WP_000213721.1 antirestriction protein -
JNN66_RS00325 74467..75285 - 819 WP_001175173.1 DUF945 domain-containing protein -
JNN66_RS00330 75375..75608 - 234 WP_001278284.1 DUF905 family protein -
JNN66_RS00335 75614..76291 - 678 WP_112018537.1 hypothetical protein -
JNN66_RS00340 76442..77122 - 681 WP_001282911.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13965.02 Da        Isoelectric Point: 8.2830

>T188548 WP_000854775.1 NZ_CP068823:c72487-72113 [Escherichia coli]
MKTLPDTLVREASRCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAK

Download         Length: 375 bp

>T188548 NZ_CP090506:c482842-482537 [Xylella fastidiosa subsp. morus]
ATGAATAATGAGACTTTTAGTCGATACGACACCGCTGACTATCTCAAAACCGAAGAAGATATTGCGGCTTATATGGAAGC
CGTCATGGAAGAAGGTGGTAGGGATAATCCTGCTTTTATTGCACGGGCACTTGGTGCTGTCGCTCGTGCTCGTAATTTAA
GTCAACTTGCTCGTGACGTTGGCATGTCCAGGCAAGGACTAGACAAGGCACTCTCTATCGACGGCAACCCAAGCTTCTCA
ACCATCTTAAAAGTGGCTAAAGCGCTTGGTTTACGGATGTCATTCACACCTTCCTCTATGAGTTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13678.37 Da        Isoelectric Point: 5.4492

>AT188548 WP_001285645.1 NZ_CP068823:c72945-72577 [Escherichia coli]
VSDTLSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRADIRGRFSDADAYHLDQAFPLLMKQLELMLTNG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT188548 NZ_CP090506:c483142-482846 [Xylella fastidiosa subsp. morus]
ATGGTCGAACTCATCAAAACCAGCACTTTTGATGCTTGGATAAACAGCTTACGTGACCGCAAAGCAGCCGCCAGAATTCA
AGCACGTCTTGATCGGCTCGCACTTGGCAATCCCGGCGACGTGAAGCCTGTGGGGGCTGGCATATCAGAAATGAGGATCG
ACCATGGGCCCGGATATCGGATCTATTTTATGAAGCATGGTGCAGTACTGATCCTCTTACTTTGCGGTGGCGATAAATCG
TCACAAGTACGAGATATAGAGCAGGCTAAGGCACTGGCTGCACTATGGAAGGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E3PN67

Antitoxin

Source ID Structure
AlphaFold DB A0A426P7N5

References