Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4406585..4407420 Replicon chromosome
Accession NZ_CP068822
Organism Escherichia coli strain RIVM_C029324

Toxin (Protein)


Gene name yeeV Uniprot ID Q1R2L4
Locus tag JNN44_RS21120 Protein ID WP_001094426.1
Coordinates 4406585..4406962 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID Q1R2L5
Locus tag JNN44_RS21125 Protein ID WP_001285575.1
Coordinates 4407052..4407420 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN44_RS21095 4402088..4402267 + 180 WP_001298063.1 hypothetical protein -
JNN44_RS21100 4402666..4404702 - 2037 WP_000417001.1 hypothetical protein -
JNN44_RS21105 4405654..4405812 - 159 WP_001467148.1 hypothetical protein -
JNN44_RS21110 4405891..4406088 - 198 WP_000839272.1 DUF957 domain-containing protein -
JNN44_RS21115 4406100..4406588 - 489 WP_000761683.1 hypothetical protein -
JNN44_RS21120 4406585..4406962 - 378 WP_001094426.1 TA system toxin CbtA family protein Toxin
JNN44_RS21125 4407052..4407420 - 369 WP_001285575.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JNN44_RS21130 4407500..4407721 - 222 WP_000692350.1 DUF987 domain-containing protein -
JNN44_RS21135 4407808..4408284 - 477 WP_001298074.1 RadC family protein -
JNN44_RS21140 4408299..4408784 - 486 WP_000213697.1 antirestriction protein -
JNN44_RS21145 4408875..4409693 - 819 WP_001175160.1 DUF945 domain-containing protein -
JNN44_RS21150 4409783..4410016 - 234 WP_001278290.1 DUF905 family protein -
JNN44_RS21155 4410022..4410699 - 678 WP_001097301.1 hypothetical protein -
JNN44_RS21160 4410847..4411527 - 681 WP_001282919.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14072.99 Da        Isoelectric Point: 7.3523

>T188545 WP_001094426.1 NZ_CP068822:c4406962-4406585 [Escherichia coli]
MNTLPDTHIREASHCQSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T188545 NZ_CP090505:c18787-18518 [Xylella fastidiosa subsp. morus]
ATGGCATGGAAGGTTGAGCTTTCGTCGTTGGCTCAAAAAAACCTTGATCAGCTTGACCCACAAATTGCCCTGCGTGTCCT
ATCATTTCTCCATGAGCGTGTGGCTCCTTTGGACGATCCGCGCAGCATCGGTGAATCCCTCAAGGGTTCGCGCCTTGGTG
AGTTTTGGAAGTACCGCGTGGGTGATTACCGGATTATCAGCAGCATTGAGGACGGCGCTTTGCGCATCCTCGTTGTGAAG
ATTGGCAACCGCCGCGAGGTTTACCGCTAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13709.52 Da        Isoelectric Point: 6.6258

>AT188545 WP_001285575.1 NZ_CP068822:c4407420-4407052 [Escherichia coli]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKRLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT188545 NZ_CP090505:c19001-18771 [Xylella fastidiosa subsp. morus]
ATGGCCTCCGTATCACTGCGTTTGCCTGATGAAGTTACACAACGACTTGAGAACTTAGCAGCGCTCACAGGGCGTAGCAA
AACCTTCTACATGGTGGAAGCCATCCGCGAACACATCGACGACCTAGAAGACTTGTACCTAGCCGAGCGTGAGCTTGAAG
CGATCCGTTCTGGCAATTCGCAAACCGTACCACTCGAAGAAGTGATGCAACGCTATGGCATGGAAGGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454ABD6

Antitoxin

Source ID Structure
AlphaFold DB A0A454ABF5

References