Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3170733..3171577 Replicon chromosome
Accession NZ_CP068822
Organism Escherichia coli strain RIVM_C029324

Toxin (Protein)


Gene name yeeV Uniprot ID B1LJY4
Locus tag JNN44_RS15125 Protein ID WP_000854686.1
Coordinates 3170733..3171116 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A8E0J1S3
Locus tag JNN44_RS15130 Protein ID WP_001285602.1
Coordinates 3171197..3171577 (-) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN44_RS15095 3167409..3168113 + 705 WP_001241673.1 leucyl/phenylalanyl-tRNA--protein transferase -
JNN44_RS15100 3168398..3168616 + 219 WP_001040187.1 translation initiation factor IF-1 -
JNN44_RS15110 3169107..3169949 - 843 WP_001431817.1 DUF4942 domain-containing protein -
JNN44_RS15115 3170034..3170231 - 198 WP_000839253.1 DUF957 domain-containing protein -
JNN44_RS15120 3170248..3170736 - 489 WP_001054233.1 hypothetical protein -
JNN44_RS15125 3170733..3171116 - 384 WP_000854686.1 TA system toxin CbtA family protein Toxin
JNN44_RS15130 3171197..3171577 - 381 WP_001285602.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JNN44_RS15135 3171588..3172271 - 684 WP_000086768.1 hypothetical protein -
JNN44_RS15140 3172290..3172511 - 222 WP_000692298.1 DUF987 domain-containing protein -
JNN44_RS15145 3172574..3173050 - 477 WP_001186726.1 RadC family protein -
JNN44_RS15150 3173066..3173551 - 486 WP_000214307.1 antirestriction protein -
JNN44_RS15155 3173643..3174461 - 819 WP_001234732.1 DUF945 domain-containing protein -
JNN44_RS15160 3174561..3174794 - 234 WP_001119719.1 DUF905 family protein -
JNN44_RS15165 3174873..3175328 - 456 WP_001504120.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-113)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14272.28 Da        Isoelectric Point: 6.8614

>T188532 WP_000854686.1 NZ_CP068822:c3171116-3170733 [Escherichia coli]
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGAPSSQLINSIDILRARRATGLMTRDNYRMVNNITLGKHPEEAKQ

Download         Length: 384 bp

>T188532 NZ_CP090504:c530518-530219 [Xylella fastidiosa subsp. morus]
ATGACCTACACGGTAAAACGACTTGAAGGGTTCTCTGACTGGCTAAAGGGCCTAAAGGATGGGCTGGCAAGGCAGCGCCT
CATCAAGCGCTTACGCAAGGTGCAGCTCGGCAACTTTGGAGACGTGCAGCCAGTGGGTGAAGGCGTGTTTGAAATGCGCG
AACACTTCGGACCTGGCTGGCGTATGTACTACGTGCAGCGAGGCAGCTTTCTCATCGTGATGCTCGGCGGCGGCGACAAG
TCAACGCAGCAATCAGACATTCGTCGGGCCATTGAGCTAGCAAAATCTTTAGAGGATTGA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13938.69 Da        Isoelectric Point: 5.0823

>AT188532 WP_001285602.1 NZ_CP068822:c3171577-3171197 [Escherichia coli]
VSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Download         Length: 381 bp

>AT188532 NZ_CP090504:c530215-529907 [Xylella fastidiosa subsp. morus]
GTGACCATCACAAAGAAAATCAATGTCTCCGAACTGCCAGAGTTCGATGCCGCCGAATACCTGAACAGCGAAGAGGAGGT
AGCCGCGTATCTCACGGCTGTTCTTGAAGAAAACGATCCAGCACTGTTAGCGGCTGCGCTGGGTGACATTGCCCGTTCAC
GTGGTATGTCTCAGATTGCGAAGGATTCTGGCATCACGCGGGAAGCTCTATACAAGGCTCTTCGGCCTGGCAGTGAACCA
CGCTTCGATACGATAAGCCGCGTCTGTACCGCCCTAGGTATACGTCTAGTAGCGCAACCAATGCATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References