Detailed information of TA system TA188511

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 4770559..4771393
• Replicon: chromosome
• Accession: NZ_CP068821
• Organism: Escherichia coli strain RIVM_C029952

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: B7MK10
• Locus tag: JNN43_RS23260
• Protein ID: WP_000854820.1
• Coordinates: 4771016..4771393 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: B7MK11
• Locus tag: JNN43_RS23255
• Protein ID: WP_001285610.1
• Coordinates: 4770559..4770927 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JNN43_RS23215	4766280..4766960	+	681	WP_021515201.1	WYL domain-containing protein	-
JNN43_RS23220	4767111..4767788	+	678	WP_060579144.1	hypothetical protein	-
JNN43_RS23225	4767794..4768027	+	234	WP_000883181.1	DUF905 family protein	-
JNN43_RS23230	4768117..4768935	+	819	WP_001175155.1	DUF945 domain-containing protein	-
JNN43_RS23235	4768961..4769101	-	141	WP_000997937.1	hypothetical protein	-
JNN43_RS23240	4769201..4769680	+	480	WP_000706978.1	antirestriction protein	-
JNN43_RS23245	4769695..4770171	+	477	WP_001186193.1	RadC family protein	-
JNN43_RS23250	4770258..4770479	+	222	WP_000692347.1	DUF987 domain-containing protein	-
JNN43_RS23255	4770559..4770927	+	369	WP_001285610.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
JNN43_RS23260	4771016..4771393	+	378	WP_000854820.1	type IV toxin-antitoxin system toxin CbtA	Toxin
JNN43_RS23265	4771390..4771587	+	198	Protein_4552	hypothetical protein	-
JNN43_RS23270	4771615..4771812	+	198	WP_085949158.1	DUF957 domain-containing protein	-
JNN43_RS23275	4771897..4772457	+	561	Protein_4554	DUF4942 domain-containing protein	-
JNN43_RS23280	4773292..4774830	+	1539	WP_001187178.1	lysine decarboxylation/transport transcriptional activator CadC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4737268..4782643	45375

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (19-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14043.12 Da
• Isoelectric Point: 7.8839

>T188511 WP_000854820.1 NZ_CP068821:4771016-4771393 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNIILGKHPEVKQ

Nucleotide

• Length: 378 bp

>T188511 NZ_CP090484:926889-927470 [Burkholderia sp. S-53]
ATGAACCCCGACACGATCCACGCGCGCCTCGATTTCCTGCGCGAAGCCGAACGCCTGAAGGATGTGCTGCGCAGCGGCCA
TACGTCGGCCGGGCGTGCGGAAAGCACGGCCGAGCACAGCTGGCGGCTGTGCCTGATGGCGCTCGTGTTCGCCGACGCGC
TGCCCGGCATCGATACGCTGAAGCTGCTGAAACTGTGCGTCGTCCACGATCTCGGCGAGGCGCTGCACGGCGACATTCCC
GCGATCGAGCAGGCCGCGCACCCGGACAAAAGCGCGCACGAACGCAACGACCTGCTGACGCTGACGTCGTCGCTCGACCG
CACGCTGCGCGACGAGATCGTCGCGCTGTGGGAGGAATACGACGCGGCCGCGTCGCCGGAAGCACGCGCGGCGAAGGCGC
TCGACAAGCTCGAGACAATCCTGCAGCACAACCAGGGCAGCAATCCTCCCGATTTCGACTACGCGTTCAATCTCGGCTAC
GGCCGGCGCTATACCGATGCCGCGCCGCTGTTCAGTACGATCCGCGACATCGTCGATGCCGATACGCAACGCAGGATCGA
CGCGGGCGGGCACCGCGCGTAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13606.39 Da
• Isoelectric Point: 6.0618

>AT188511 WP_001285610.1 NZ_CP068821:4770559-4770927 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Nucleotide

• Length: 369 bp

>AT188511 NZ_CP090484:926252-926809 [Burkholderia sp. S-53]
ATGACCGCCTCTCCGCTTCACACGCCGCCGCTCGGCCCGCAGCTCAAGCGCTGGCGCGCGCTGCACCGCGTGAAGCAGAG
TCACGCGGCCGAACTGTTCGGCGTCGCGCAATCGACGATCTCCCGCTGGGAAGCCGGCCTGCAGCAGATGTCGGCCGACG
AGCGCGCGACGGCCGAGCGGCTGCTCGCCGCGCGCCTCGATTCCGCGGGCGACCATGCGCTCGCGCGGCTCATCGCGGGC
AGCGCGGGCCGCATGCATCTCGTGTGCGATCTCACGCACCGCCTGCTCGCCAGTTCGCCGGCGCGCGCGGCGGAGTTCTC
GCAACCGCTGCCGACGCTGCTCGGCACGTCGCTGTGGCGCTACGCGACGCCGGAAATCGTCCGCATGGAAACCGCGCTCG
ACACGCTCGGCTGGCGCGACCGCGCGGGGCCGCCGAGCGTCGAATTCGCGACCGGCACGAATGCGTCGCGCGTCGTGCCG
ATCCGCGGCAGCACGTGCCGGTGGACGCGGATGACGCTGTCGGACGGTTCGGCCTCCCGGCTCGTGGAAACGCTGTAG

Structures

Toxin

• AlphaFold DB: A0A0E2KXX6