188510

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4623612..4624207 Replicon chromosome
Accession NZ_CP068821
Organism Escherichia coli strain RIVM_C029952

Toxin (Protein)


Gene name chpB Uniprot ID A0A0V9NWK6
Locus tag JNN43_RS22440 Protein ID WP_019842229.1
Coordinates 4623612..4623962 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag JNN43_RS22445 Protein ID WP_001223213.1
Coordinates 4623956..4624207 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN43_RS22420 4618942..4619964 - 1023 WP_001550507.1 ABC transporter permease -
JNN43_RS22425 4619978..4621480 - 1503 WP_001550506.1 sugar ABC transporter ATP-binding protein -
JNN43_RS22430 4621612..4622568 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
JNN43_RS22435 4622878..4623408 + 531 WP_000055075.1 inorganic diphosphatase -
JNN43_RS22440 4623612..4623962 - 351 WP_019842229.1 endoribonuclease toxin ChpB Toxin
JNN43_RS22445 4623956..4624207 - 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
JNN43_RS22450 4624419..4624760 - 342 WP_001550504.1 gamma-glutamylcyclotransferase -
JNN43_RS22455 4624763..4628542 - 3780 WP_001550503.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-115)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12483.44 Da        Isoelectric Point: 5.6097

>T188510 WP_019842229.1 NZ_CP068821:c4623962-4623612 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVWMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

>T188510 NZ_CP090484:832596-832862 [Burkholderia sp. S-53]
ATGAGCGTACGCCGCGTGCTCTTTACTTCCGACGCGTGGGACGACTATGTTTATTGGCAAGGGCAGGATCGCAAGACGCT
CAAGCGCATCAACCAGCTCATTCGCGAAGCCCAGCGAACGCCGTTCGAAGGCATCGGCAAACCTGAACCGTTGAAGGCCA
ATCTCTCCGGCTTCTGGTCGCGCCGTATCGACGACACAAACCGCCTGGTCTACGAGGCTGACGACCTTCAGATCAGCATC
GTGTCCTGTCGCTACCACTACGAGTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT188510 WP_001223213.1 NZ_CP068821:c4624207-4623956 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT188510 NZ_CP090484:832339-832599 [Burkholderia sp. S-53]
ATGCGCACGATTCATTTTTCGGATGCCCGCGGCAATCTGAAGACCGTCATCGATCAGGTCGTCGACGATGCGGACGTGAC
GCTCATCACGCGTCGCGATGCACCGAACGCCGTCATCATGTCGCAGGACTACTACGACAGCCTGATGGAGACAGTTCACT
TGCTGCGCACGCCGGCCAACGTCGCCCATCTCGAACGTTCGATCGCGCAACTGCGCAAGGGCAAGACGAAAGAACACAAG
CTCGCCGAGGATGATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V9NWK6

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References