Detailed information of TA system TA188508

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4504794..4505614
• Replicon: chromosome
• Accession: NZ_CP068821
• Organism: Escherichia coli strain RIVM_C029952

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: A0A0V9MKL8
• Locus tag: JNN43_RS21840
• Protein ID: WP_001550554.1
• Coordinates: 4504794..4505051 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: JNN43_RS21845
• Protein ID: WP_001519303.1
• Coordinates: 4505063..4505614 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JNN43_RS21820	4500080..4501186	+	1107	WP_001519308.1	N-acetylneuraminate epimerase	-
JNN43_RS21825	4501251..4502231	+	981	WP_001519307.1	transposase	-
JNN43_RS21830	4502814..4504055	-	1242	Protein_4271	helicase YjhR	-
JNN43_RS21835	4504118..4504417	+	300	WP_001519304.1	GNAT family N-acetyltransferase	-
JNN43_RS21840	4504794..4505051	+	258	WP_001550554.1	hypothetical protein	Toxin
JNN43_RS21845	4505063..4505614	+	552	WP_001519303.1	N-acetyltransferase	Antitoxin
JNN43_RS21850	4505666..4505827	+	162	WP_001519302.1	hypothetical protein	-
JNN43_RS21855	4505864..4506412	+	549	WP_001519301.1	hypothetical protein	-
JNN43_RS21860	4506539..4506799	+	261	WP_000084876.1	hypothetical protein	-
JNN43_RS21865	4506837..4506953	+	117	Protein_4278	VOC family protein	-
JNN43_RS21870	4507198..4508319	+	1122	WP_000010833.1	M42 family metallopeptidase	-
JNN43_RS21875	4508316..4508594	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
JNN43_RS21880	4508606..4509919	+	1314	WP_001519300.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimE / fimB	4496204..4505827	9623

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9744.33 Da
• Isoelectric Point: 11.0090

>T188508 WP_001550554.1 NZ_CP068821:4504794-4505051 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKPVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T188508 NZ_CP090484:c751084-750665 [Burkholderia sp. S-53]
ATGATCCTTGTTGATACGAATGTCATTTCCGAACCGCTGCGACGCGAGCCGAGCGCAGCCGTGATCGAGTGGCTCGATGC
CCAGAACGTCGAGACGCTGTTTCTTGCCGCGATCAGTCTCGCGGAGATACGATTCGGCGTGGCTGTAATGCCGGAAGGGC
GCAGGCGCGAGTGGCTGCATCGAAGCATCGAACAGCGTGTCGTGCCATTGTTTCGAGGTCGGATCCTGCCGTTCGACGAT
GCGGCGAGCAAAGCGTATGCGAGCGTTCGGGCGCGGGCCCGTGTCGCAGGTAATGCGATCGCGCCTGTCGATGGTTTTAT
CGCCGCCACGGCCGACGCGAACGGCCTGATCGTGGCCACGCGCGACGTCGCGCCGTTCGAGGCGGTGGGGCTTCGCGTGA
TCGATCCGTGGGCGCGGTAG

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20463.61 Da
• Isoelectric Point: 6.8758

>AT188508 WP_001519303.1 NZ_CP068821:4505063-4505614 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT188508 NZ_CP090484:c751320-751081 [Burkholderia sp. S-53]
ATGCCGGTGATCACCGTTCGAAATTTGCCCGATGAAGTGCATCGCGCACTTCGTATTCGCGCGGCCCAGCACGGGCGCAG
CACCGAAGCCGAGGTGCGTGACATTCTCGAGCAGGCCGTCCTGCCAGGCGGGCGGCTCAAGCTGGGAACGTTGCTGGCGG
AAATCGGGCGGGAGGCTGGGGGAGTCGATTTCGACGTCCAGCGCGACAAGACGTCAACCGATCCGATGAGCTTCGAATGA

Structures

Toxin

• AlphaFold DB: A0A0V9MKL8