Detailed information of TA system TA188505

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4036019..4037708
• Replicon: chromosome
• Accession: NZ_CP068821
• Organism: Escherichia coli strain RIVM_C029952

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: V0Z9M0
• Locus tag: JNN43_RS19500
• Protein ID: WP_000365809.1
• Coordinates: 4036019..4036939 (-)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: JNN43_RS19505
• Protein ID: WP_001550661.1
• Coordinates: 4036926..4037708 (-)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JNN43_RS19485	4032109..4033236	-	1128	WP_001550663.1	MFS transporter	-
JNN43_RS19490	4033378..4034436	-	1059	WP_122987197.1	alpha/beta hydrolase	-
JNN43_RS19495	4034701..4035585	+	885	WP_001119037.1	LysR family transcriptional regulator	-
JNN43_RS19500	4036019..4036939	-	921	WP_000365809.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
JNN43_RS19505	4036926..4037708	-	783	WP_001550661.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
JNN43_RS19510	4038024..4041233	+	3210	WP_001521910.1	RNA-directed DNA polymerase	-
JNN43_RS19515	4041394..4041534	+	141	WP_001308408.1	ash family protein	-
JNN43_RS19520	4041580..4042050	+	471	WP_000201185.1	hypothetical protein	-
JNN43_RS19525	4042047..4042149	+	103	Protein_3821	helix-turn-helix domain-containing protein	-
JNN43_RS19530	4042241..4042399	+	159	Protein_3822	integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-261)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (95-247)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34571.01 Da
• Isoelectric Point: 7.2649

>T188505 WP_000365809.1 NZ_CP068821:c4036939-4036019 [Escherichia coli]
MDLRDSYARQVKLLMAALPYVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLEKPGLMREIFDGFLCYLAGHPRPIAELLAPNWDTERIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHLTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAVLKDKNPAKYVAAVNKLERVLA

Nucleotide

• Length: 921 bp

>T188505 NZ_CP090484:289361-289657 [Burkholderia sp. S-53]
ATGGAAAAACACACGCCTCATTGCAAGCTGTCTCGGGTCCGAACGCTCATCGAGAACGGCAACGTGCGTTTGACCGCGAG
TGCGGTATTCGGCGCCCGGCAACTCGGTTTTACGGAACAGGAGGCTGTCGGTGTCGTCATGTCGCTGACAGCGGTCGATT
TCTACAAGAGCATGACGACGTATGCCGACCATACGATCTGGCAAGACGTCTATCAACGTCGTACCGTCCGTGGCGACGTG
TACCTGAAACTGACGGTGATCGACGACGTGCTGATCGTGTCTTTCAAGGAGCGGTGA

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29191.43 Da
• Isoelectric Point: 8.9059

>AT188505 WP_001550661.1 NZ_CP068821:c4037708-4036926 [Escherichia coli]
MPNYLNWLMQHTLPGQVLLQSWLTRNGIDRKLSYLYVKNGWLRRIAHGVYCRTGREPDWVDAVYCLQSQWEKPVRVAGLT
SLALQGHAHYTEQGKPQVWLALPAYVKLPGWFSAFEQSATFVTLYTSGLTADVTPFTTELKIGDRQLAGSVPELAAYEIA
CGVPSLISFEHADALFQGLNLLSPRKLQALLRASHSVKTNRVMLYLARRNGHPYFQYIDQSGIETGTGKRQIIPGGWLEP
DYQITVPRAFKPEGVEDGSA

Nucleotide

• Length: 783 bp

>AT188505 NZ_CP090484:289660-290061 [Burkholderia sp. S-53]
ATGAAGTGCCCTGCCTGCGGTGCCGCCAAACTGGTCCGCGATACGCGAGACATTCCCTATACGTACAAGGGTCGATCGAC
CGTCGTCCGCGATATCACCGGTGATTTCTGCCCGGCCTGCGGAGAGTCGGTCCTTGATCTCGACGAGGCGACCCGTCTCG
GCGACGCGATAACCGAGTTCAACAAACAGGTGAATTCGACCATCGTCGACCCGAAGTTCATTTCGAAGGTCCGCAAGAAG
CTGCGGCTGGATCAGCGCGAGGCGGCCGAAATATTCGGTGGCGGTGTCAATGCGTTCTCACGTTACGAAACCGGCAAGAC
GAACCCGCCGCTTGCCCTTGTGAAGCTGTTCAGGATCCTGGATCGCCATCCGGATCTGCTCGCCGAAGTGCGAGCCGCAT
AG

Structures

Toxin

• AlphaFold DB: V0Z9M0