Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 3832294..3832912 | Replicon | chromosome |
Accession | NZ_CP068821 | ||
Organism | Escherichia coli strain RIVM_C029952 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | H5UYE2 |
Locus tag | JNN43_RS18545 | Protein ID | WP_001291435.1 |
Coordinates | 3832694..3832912 (+) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | S1PTH5 |
Locus tag | JNN43_RS18540 | Protein ID | WP_000344800.1 |
Coordinates | 3832294..3832668 (+) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JNN43_RS18530 | 3827383..3828576 | + | 1194 | WP_001295833.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
JNN43_RS18535 | 3828599..3831748 | + | 3150 | WP_001132480.1 | multidrug efflux RND transporter permease subunit | - |
JNN43_RS18540 | 3832294..3832668 | + | 375 | WP_000344800.1 | Hha toxicity modulator TomB | Antitoxin |
JNN43_RS18545 | 3832694..3832912 | + | 219 | WP_001291435.1 | hemolysin expression modulator Hha | Toxin |
JNN43_RS18550 | 3833084..3833635 | + | 552 | WP_060579167.1 | maltose O-acetyltransferase | - |
JNN43_RS18555 | 3833751..3834221 | + | 471 | WP_000136192.1 | YlaC family protein | - |
JNN43_RS18560 | 3834385..3835935 | + | 1551 | WP_001366446.1 | cyclic-guanylate-specific phosphodiesterase PdeB | - |
JNN43_RS18565 | 3835977..3836330 | - | 354 | WP_001550741.1 | DUF1428 family protein | - |
JNN43_RS18575 | 3836709..3837020 | + | 312 | WP_000409911.1 | MGMT family protein | - |
JNN43_RS18580 | 3837051..3837623 | - | 573 | WP_000779831.1 | YbaY family lipoprotein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8628.00 Da Isoelectric Point: 8.9008
>T188504 WP_001291435.1 NZ_CP068821:3832694-3832912 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
Download Length: 219 bp
>T188504 NZ_CP090484:198449-198862 [Burkholderia sp. S-53]
ATGAGCGGGATTGAGTCGGCGAAATCGTTCGTCGACAGCAATGTCGTGCTTTATCTGCTGTCCGAGGACGAAACCAAGGC
GGATCGGGCGGAGGCGCTGTTCCTTCGGCGGCCGACCATCAGTGTCCAGGTACTGAACGAAGTCGCCAGCGTGTGCAGTC
GAAAATTGCGGATGCCGTGGAGCGATGTGGGGCAGTTTCTGGAACCGATCAGGAGCTTGTGCCATGTCGTACCGGTCACG
ATCGATACGCATGACCTGGCGCGAAGGCTCGCGGAACGGCATGGCTTGTCCTTCTATGACGCGTGCATCGTCGCCGCCGC
GTCGCTCGAGGGCTGCGAGTACCTGTACACCGAGGACATGCACGACGGCCTGCGCGTGGACGGCGGTCCGGTACTGCGAA
ATCCGTTTGCCTGA
ATGAGCGGGATTGAGTCGGCGAAATCGTTCGTCGACAGCAATGTCGTGCTTTATCTGCTGTCCGAGGACGAAACCAAGGC
GGATCGGGCGGAGGCGCTGTTCCTTCGGCGGCCGACCATCAGTGTCCAGGTACTGAACGAAGTCGCCAGCGTGTGCAGTC
GAAAATTGCGGATGCCGTGGAGCGATGTGGGGCAGTTTCTGGAACCGATCAGGAGCTTGTGCCATGTCGTACCGGTCACG
ATCGATACGCATGACCTGGCGCGAAGGCTCGCGGAACGGCATGGCTTGTCCTTCTATGACGCGTGCATCGTCGCCGCCGC
GTCGCTCGAGGGCTGCGAGTACCTGTACACCGAGGACATGCACGACGGCCTGCGCGTGGACGGCGGTCCGGTACTGCGAA
ATCCGTTTGCCTGA
Antitoxin
Download Length: 125 a.a. Molecular weight: 14557.39 Da Isoelectric Point: 4.7395
>AT188504 WP_000344800.1 NZ_CP068821:3832294-3832668 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC
Download Length: 375 bp
>AT188504 NZ_CP090484:198229-198462 [Burkholderia sp. S-53]
ATGCAGGTCGCAAAGTGGGGCAATAGCCTGGCCGTCCGCCTTCCCGCCAGTGTGGTCGATGCACTGGAGCTCCGTGAAGG
GGACGATATCGAAATCGTGGTCGATAGCCCGCGCGTTTTTGCCGTCAGCCGCAAGCCGCGGGCCGATGAACTTCTGCAAC
GGTTGCGGCGTTTCAGGGGCAAGCTGCCCGCCGATTTCAAGTTCAGCCGGGACGACGCGAATGAGCGGGATTGA
ATGCAGGTCGCAAAGTGGGGCAATAGCCTGGCCGTCCGCCTTCCCGCCAGTGTGGTCGATGCACTGGAGCTCCGTGAAGG
GGACGATATCGAAATCGTGGTCGATAGCCCGCGCGTTTTTGCCGTCAGCCGCAAGCCGCGGGCCGATGAACTTCTGCAAC
GGTTGCGGCGTTTCAGGGGCAAGCTGCCCGCCGATTTCAAGTTCAGCCGGGACGACGCGAATGAGCGGGATTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
PDB | 2MW2 | |
PDB | 1JW2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9QBQ5 |