Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1988860..1989691 Replicon chromosome
Accession NZ_CP068821
Organism Escherichia coli strain RIVM_C029952

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag JNN43_RS09465 Protein ID WP_000854814.1
Coordinates 1988860..1989234 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag JNN43_RS09470 Protein ID WP_001285585.1
Coordinates 1989323..1989691 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN43_RS09425 1984256..1985422 + 1167 WP_202852041.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
JNN43_RS09430 1985541..1986014 + 474 WP_001105415.1 DNA gyrase inhibitor SbmC -
JNN43_RS09435 1986212..1987270 + 1059 WP_001200891.1 FUSC family protein -
JNN43_RS09440 1987442..1987771 + 330 WP_000450409.1 DUF496 family protein -
JNN43_RS09445 1987872..1988054 - 183 WP_001016348.1 hypothetical protein -
JNN43_RS09450 1988126..1988254 + 129 Protein_1848 transposase domain-containing protein -
JNN43_RS09455 1988543..1988656 - 114 WP_001161660.1 DUF957 domain-containing protein -
JNN43_RS09460 1988669..1988863 - 195 WP_000988600.1 hypothetical protein -
JNN43_RS09465 1988860..1989234 - 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
JNN43_RS09470 1989323..1989691 - 369 WP_001285585.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
JNN43_RS09475 1989765..1989986 - 222 WP_000692323.1 DUF987 domain-containing protein -
JNN43_RS09480 1990049..1990525 - 477 WP_202852042.1 RadC family protein -
JNN43_RS09485 1990541..1991020 - 480 WP_000860087.1 antirestriction protein -
JNN43_RS09490 1991102..1991920 - 819 WP_060626401.1 DUF945 domain-containing protein -
JNN43_RS09495 1992020..1992253 - 234 WP_001119729.1 DUF905 family protein -
JNN43_RS09500 1992328..1992783 - 456 WP_000581504.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T188485 WP_000854814.1 NZ_CP068821:c1989234-1988860 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T188485 NZ_CP090468:c3939048-3938731 [Klebsiella pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT188485 WP_001285585.1 NZ_CP068821:c1989691-1989323 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT188485 NZ_CP090468:c3938738-3938451 [Klebsiella pneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCGACAGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References