Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3362400..3363232 Replicon chromosome
Accession NZ_CP068820
Organism Escherichia coli strain RIVM_C029951

Toxin (Protein)


Gene name yeeV Uniprot ID E3PN67
Locus tag JNN41_RS16140 Protein ID WP_000854775.1
Coordinates 3362400..3362774 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A426P7N5
Locus tag JNN41_RS16145 Protein ID WP_001285645.1
Coordinates 3362864..3363232 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN41_RS16110 3357764..3358687 - 924 WP_000535949.1 carboxylate/amino acid/amine transporter -
JNN41_RS16115 3358798..3359982 - 1185 WP_001172876.1 sugar efflux transporter -
JNN41_RS16120 3360410..3360592 - 183 WP_177309578.1 hypothetical protein -
JNN41_RS16125 3360776..3361618 - 843 WP_001274548.1 DUF4942 domain-containing protein -
JNN41_RS16130 3361703..3361900 - 198 WP_000772035.1 DUF957 domain-containing protein -
JNN41_RS16135 3361912..3362403 - 492 WP_000976825.1 hypothetical protein -
JNN41_RS16140 3362400..3362774 - 375 WP_000854775.1 TA system toxin CbtA family protein Toxin
JNN41_RS16145 3362864..3363232 - 369 WP_001285645.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JNN41_RS16150 3363395..3363616 - 222 WP_000692303.1 DUF987 domain-containing protein -
JNN41_RS16155 3363685..3364161 - 477 WP_001318130.1 RadC family protein -
JNN41_RS16160 3364177..3364662 - 486 WP_000213721.1 antirestriction protein -
JNN41_RS16165 3364754..3365572 - 819 WP_001175173.1 DUF945 domain-containing protein -
JNN41_RS16170 3365662..3365895 - 234 WP_001278284.1 DUF905 family protein -
JNN41_RS16175 3365901..3366578 - 678 WP_001097567.1 hypothetical protein -
JNN41_RS16180 3366729..3367409 - 681 WP_001282911.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13965.02 Da        Isoelectric Point: 8.2830

>T188470 WP_000854775.1 NZ_CP068820:c3362774-3362400 [Escherichia coli]
MKTLPDTLVREASRCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAK

Download         Length: 375 bp

>T188470 NZ_CP090462:c4814072-4813539 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13678.37 Da        Isoelectric Point: 5.4492

>AT188470 WP_001285645.1 NZ_CP068820:c3363232-3362864 [Escherichia coli]
VSDTLSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRADIRGRFSDADAYHLDQAFPLLMKQLELMLTNG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT188470 NZ_CP090462:c4814349-4814083 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E3PN67

Antitoxin

Source ID Structure
AlphaFold DB A0A426P7N5

References