188467

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2773792..2774627 Replicon chromosome
Accession NZ_CP068820
Organism Escherichia coli strain RIVM_C029951

Toxin (Protein)


Gene name yeeV Uniprot ID A0A3P5DZK2
Locus tag JNN41_RS13505 Protein ID WP_060578072.1
Coordinates 2774250..2774627 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A3P5E0D5
Locus tag JNN41_RS13500 Protein ID WP_060578073.1
Coordinates 2773792..2774160 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN41_RS13465 2769575..2770246 + 672 WP_060578077.1 hypothetical protein -
JNN41_RS13470 2770259..2770669 + 411 WP_060578076.1 hypothetical protein -
JNN41_RS13475 2770890..2771708 + 819 WP_060578075.1 DUF945 domain-containing protein -
JNN41_RS13480 2771800..2772285 + 486 WP_000214415.1 antirestriction protein -
JNN41_RS13485 2772301..2772777 + 477 WP_001186726.1 RadC family protein -
JNN41_RS13490 2772846..2773067 + 222 WP_000692323.1 DUF987 domain-containing protein -
JNN41_RS13495 2773086..2773781 + 696 WP_060578074.1 hypothetical protein -
JNN41_RS13500 2773792..2774160 + 369 WP_060578073.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JNN41_RS13505 2774250..2774627 + 378 WP_060578072.1 TA system toxin CbtA family protein Toxin
JNN41_RS13510 2774624..2775112 + 489 WP_000761718.1 hypothetical protein -
JNN41_RS13515 2775124..2775321 + 198 WP_000839256.1 DUF957 domain-containing protein -
JNN41_RS13520 2775406..2776248 + 843 WP_060578071.1 DUF4942 domain-containing protein -
JNN41_RS13525 2776997..2778535 + 1539 WP_001187178.1 lysine decarboxylation/transport transcriptional activator CadC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2762867..2786344 23477


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14208.17 Da        Isoelectric Point: 7.2920

>T188467 WP_060578072.1 NZ_CP068820:2774250-2774627 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRMVNNITQGKHPEAQQ

Download         Length: 378 bp

>T188467 NZ_CP090462:2012557-2012659 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13810.52 Da        Isoelectric Point: 6.3177

>AT188467 WP_060578073.1 NZ_CP068820:2773792-2774160 [Escherichia coli]
VSDSRHETNYPDDHNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELSPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT188467 NZ_CP090462:c2012666-2012521 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3P5DZK2

Antitoxin

Source ID Structure
AlphaFold DB A0A3P5E0D5

References