Detailed information of TA system TA188441

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4391926..4392746
• Replicon: chromosome
• Accession: NZ_CP068819
• Organism: Escherichia coli strain RIVM_C029042

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: A0A0V9MKL8
• Locus tag: JNN65_RS21200
• Protein ID: WP_001550554.1
• Coordinates: 4391926..4392183 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: JNN65_RS21205
• Protein ID: WP_001519303.1
• Coordinates: 4392195..4392746 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JNN65_RS21180	4387212..4388318	+	1107	WP_001519308.1	N-acetylneuraminate epimerase	-
JNN65_RS21185	4388383..4389363	+	981	WP_001519307.1	transposase	-
JNN65_RS21190	4389946..4391187	-	1242	Protein_4148	helicase YjhR	-
JNN65_RS21195	4391250..4391549	+	300	WP_001519304.1	GNAT family N-acetyltransferase	-
JNN65_RS21200	4391926..4392183	+	258	WP_001550554.1	hypothetical protein	Toxin
JNN65_RS21205	4392195..4392746	+	552	WP_001519303.1	N-acetyltransferase	Antitoxin
JNN65_RS21210	4392798..4392959	+	162	WP_001519302.1	hypothetical protein	-
JNN65_RS21215	4392996..4393544	+	549	WP_001519301.1	hypothetical protein	-
JNN65_RS21220	4393671..4393931	+	261	WP_000084876.1	hypothetical protein	-
JNN65_RS21225	4393969..4394085	+	117	Protein_4155	VOC family protein	-
JNN65_RS21230	4394330..4395451	+	1122	WP_000010833.1	M42 family metallopeptidase	-
JNN65_RS21235	4395448..4395726	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
JNN65_RS21240	4395738..4397051	+	1314	WP_001519300.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9744.33 Da
• Isoelectric Point: 11.0090

>T188441 WP_001550554.1 NZ_CP068819:4391926-4392183 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKPVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T188441 NZ_CP090456:697051-697365 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20463.61 Da
• Isoelectric Point: 6.8758

>AT188441 WP_001519303.1 NZ_CP068819:4392195-4392746 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT188441 NZ_CP090456:697362-697778 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Structures

Toxin

• AlphaFold DB: A0A0V9MKL8