Detailed information of TA system TA188412

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4508614..4509434
• Replicon: chromosome
• Accession: NZ_CP068818
• Organism: Escherichia coli strain RIVM_C028803

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: A0A0V9MKL8
• Locus tag: JNN48_RS22045
• Protein ID: WP_001550554.1
• Coordinates: 4508614..4508871 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: JNN48_RS22050
• Protein ID: WP_001519303.1
• Coordinates: 4508883..4509434 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JNN48_RS22025	4503900..4505006	+	1107	WP_001519308.1	N-acetylneuraminate epimerase	-
JNN48_RS22030	4505071..4506051	+	981	WP_001519307.1	transposase	-
JNN48_RS22035	4506634..4507875	-	1242	Protein_4309	helicase YjhR	-
JNN48_RS22040	4507938..4508237	+	300	WP_001519304.1	GNAT family N-acetyltransferase	-
JNN48_RS22045	4508614..4508871	+	258	WP_001550554.1	hypothetical protein	Toxin
JNN48_RS22050	4508883..4509434	+	552	WP_001519303.1	N-acetyltransferase	Antitoxin
JNN48_RS22055	4509486..4509647	+	162	WP_001519302.1	hypothetical protein	-
JNN48_RS22060	4509684..4510232	+	549	WP_001519301.1	hypothetical protein	-
JNN48_RS22065	4510359..4510619	+	261	WP_000084876.1	hypothetical protein	-
JNN48_RS22070	4510657..4510773	+	117	Protein_4316	VOC family protein	-
JNN48_RS22075	4511018..4512139	+	1122	WP_000010833.1	M42 family metallopeptidase	-
JNN48_RS22080	4512136..4512414	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
JNN48_RS22085	4512426..4513739	+	1314	WP_001519300.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9744.33 Da
• Isoelectric Point: 11.0090

>T188412 WP_001550554.1 NZ_CP068818:4508614-4508871 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKPVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T188412 NZ_CP090441:c89150-88998 [Xanthomonas arboricola]
ATGAAGCGACTGCTGACACTGATGGTACTGGGCCTGTTTTCGGCCGGCGTGATGACTGGCTGCAACACCATGGCCGGCGC
TGGCAAGGACATGCAGGGTGCAGGTGAGAAGGTCGAAAAGAAGGCCGACAATTGCAGCGACGGTAAGTGCTGA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20463.61 Da
• Isoelectric Point: 6.8758

>AT188412 WP_001519303.1 NZ_CP068818:4508883-4509434 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT188412 NZ_CP090441:c88915-88781 [Xanthomonas arboricola]
ATGAAGCGTGCAATTGTGCTGCTGGTGCTGTCGGTGTTGTCGGTCGGTATGCTGTCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCTGCGCGCAAGTAA

Structures

Toxin

• AlphaFold DB: A0A0V9MKL8