188407

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3417441..3418146 Replicon chromosome
Accession NZ_CP068818
Organism Escherichia coli strain RIVM_C028803

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag JNN48_RS16800 Protein ID WP_000539521.1
Coordinates 3417441..3417827 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag JNN48_RS16805 Protein ID WP_001280945.1
Coordinates 3417817..3418146 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN48_RS16780 3413445..3414071 + 627 WP_001295292.1 glutathione S-transferase GstB -
JNN48_RS16785 3414068..3415183 - 1116 WP_000555051.1 aldose sugar dehydrogenase YliI -
JNN48_RS16790 3415294..3415677 - 384 WP_000497137.1 biofilm formation regulator BssR -
JNN48_RS16795 3415890..3417215 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
JNN48_RS16800 3417441..3417827 + 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JNN48_RS16805 3417817..3418146 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
JNN48_RS16810 3418216..3419544 - 1329 WP_001550887.1 GGDEF domain-containing protein -
JNN48_RS16815 3419552..3421900 - 2349 WP_001550886.1 EAL domain-containing protein -
JNN48_RS16820 3422078..3422989 - 912 WP_001236042.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T188407 WP_000539521.1 NZ_CP068818:3417441-3417827 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

>T188407 NZ_CP090434:133881-134030 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT188407 WP_001280945.1 NZ_CP068818:3417817-3418146 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp

>AT188407 NZ_CP090434:c133836-133777 [Klebsiella pneumoniae subsp. pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References