Detailed information of TA system TA188372

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 3202528..3203372
• Replicon: chromosome
• Accession: NZ_CP068817
• Organism: Escherichia coli strain RIVM_C028786

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: B1LJY4
• Locus tag: JNN59_RS15355
• Protein ID: WP_000854686.1
• Coordinates: 3202528..3202911 (-)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A8E0J1S3
• Locus tag: JNN59_RS15360
• Protein ID: WP_001285602.1
• Coordinates: 3202992..3203372 (-)
• Length: 127 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JNN59_RS15325	3199204..3199908	+	705	WP_001241673.1	leucyl/phenylalanyl-tRNA--protein transferase	-
JNN59_RS15330	3200193..3200411	+	219	WP_001040187.1	translation initiation factor IF-1	-
JNN59_RS15340	3200902..3201744	-	843	WP_001431817.1	DUF4942 domain-containing protein	-
JNN59_RS15345	3201829..3202026	-	198	WP_000839253.1	DUF957 domain-containing protein	-
JNN59_RS15350	3202043..3202531	-	489	WP_001054233.1	hypothetical protein	-
JNN59_RS15355	3202528..3202911	-	384	WP_000854686.1	TA system toxin CbtA family protein	Toxin
JNN59_RS15360	3202992..3203372	-	381	WP_001285602.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
JNN59_RS15365	3203383..3204066	-	684	WP_000086768.1	hypothetical protein	-
JNN59_RS15370	3204085..3204306	-	222	WP_000692298.1	DUF987 domain-containing protein	-
JNN59_RS15375	3204369..3204845	-	477	WP_001186726.1	RadC family protein	-
JNN59_RS15380	3204861..3205346	-	486	WP_000214307.1	antirestriction protein	-
JNN59_RS15385	3205438..3206256	-	819	WP_001234732.1	DUF945 domain-containing protein	-
JNN59_RS15390	3206356..3206589	-	234	WP_001119719.1	DUF905 family protein	-
JNN59_RS15395	3206668..3207123	-	456	WP_001504120.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-113)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 14272.28 Da
• Isoelectric Point: 6.8614

>T188372 WP_000854686.1 NZ_CP068817:c3202911-3202528 [Escherichia coli]
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGAPSSQLINSIDILRARRATGLMTRDNYRMVNNITLGKHPEEAKQ

Nucleotide

• Length: 384 bp

>T188372 NZ_CP090414:c1447983-1447492 [Bifidobacterium longum]
ATGACCGACGTTTCCATGCAGCGTATTTTGCTCGATACCAACGTACTGTTGGACTATTTGCTCCATCGTGATGATCATGC
CAAGATGGCGGAAGCGGTTATGGAACTTGGCGCGAAGAACAATGTTACGTTGTTGTGCGTGTCACTGTCGCTGAAGGATA
TCGCATACCTATCATCATCGGCGATTCGTAGGGAATTCAAACCGAATGAATCGGAAGTGGAGAATTTCACTCGCGGCTTT
CTGTCGTCACGGGTGCCATGGCGTTGTATCGAGCAGGTGAAGGAGATGTGTGACATCGTCGCTGTCGATGAGTCGACATG
TGATAGGGCTTTTTCCCTGCAAAAACGGCATCGGGATTTTGAAGATGATCTGATCATCGTTGCCGCGCAACAATCCGGTG
CCAACTGTGTGGTCACATCGGATGCCGAATTAATCAGTCATTTTCCCGAATATTGCAAAACACCGGCTGAAATCGTGGCG
GCACTGGAATAA

Antitoxin

Protein

• Length: 127 a.a.
• Molecular weight: 13938.69 Da
• Isoelectric Point: 5.0823

>AT188372 WP_001285602.1 NZ_CP068817:c3203372-3202992 [Escherichia coli]
VSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Nucleotide

• Length: 381 bp

>AT188372 NZ_CP090414:c1448345-1447983 [Bifidobacterium longum]
ATGACCATGGTCCAAATGAACGTTCGCATTGATGCGAAACTGAAGAACGAGGTCGAAGAAGTCCTCAAGGGCAAAGGCGT
ATCGGTAAGTGACGTAATCCGGTCGCTGTGGTTGTACATCGCCGACCGCAAGGAAGTGCCGGCATTGGAAACGACCGCCG
AAGAGCAAGCCCGCGAGGAGGAAAAGCAGCGCAAGCTGAAACTGATTCGAGAAGGTGCCGGATACGTACACAAGGAACTG
GTCAAGGCCGGACTGATCTCAGAAGACACCGACCTCATGGAAGGCCTTACCTACAAGCAGTTCCGCGACAAAATGTACGA
CGAGCAACTTGATGCGTATTACAACATGAAGAGGGCCGATTGA