Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4407347..4408182 Replicon chromosome
Accession NZ_CP068815
Organism Escherichia coli strain RIVM_C028620

Toxin (Protein)


Gene name yeeV Uniprot ID Q1R2L4
Locus tag JNN49_RS21120 Protein ID WP_001094426.1
Coordinates 4407347..4407724 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID Q1R2L5
Locus tag JNN49_RS21125 Protein ID WP_001285575.1
Coordinates 4407814..4408182 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN49_RS21095 4402850..4403029 + 180 WP_001298063.1 hypothetical protein -
JNN49_RS21100 4403428..4405464 - 2037 WP_000417001.1 hypothetical protein -
JNN49_RS21105 4406416..4406574 - 159 WP_001467148.1 hypothetical protein -
JNN49_RS21110 4406653..4406850 - 198 WP_000839272.1 DUF957 domain-containing protein -
JNN49_RS21115 4406862..4407350 - 489 WP_000761683.1 hypothetical protein -
JNN49_RS21120 4407347..4407724 - 378 WP_001094426.1 TA system toxin CbtA family protein Toxin
JNN49_RS21125 4407814..4408182 - 369 WP_001285575.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JNN49_RS21130 4408262..4408483 - 222 WP_000692350.1 DUF987 domain-containing protein -
JNN49_RS21135 4408570..4409046 - 477 WP_001298074.1 RadC family protein -
JNN49_RS21140 4409061..4409546 - 486 WP_000213697.1 antirestriction protein -
JNN49_RS21145 4409637..4410455 - 819 WP_001175160.1 DUF945 domain-containing protein -
JNN49_RS21150 4410545..4410778 - 234 WP_001278290.1 DUF905 family protein -
JNN49_RS21155 4410784..4411461 - 678 WP_001097301.1 hypothetical protein -
JNN49_RS21160 4411609..4412289 - 681 WP_001282919.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14072.99 Da        Isoelectric Point: 7.3523

>T188317 WP_001094426.1 NZ_CP068815:c4407724-4407347 [Escherichia coli]
MNTLPDTHIREASHCQSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T188317 NZ_CP090398:c5376282-5375899 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13709.52 Da        Isoelectric Point: 6.6258

>AT188317 WP_001285575.1 NZ_CP068815:c4408182-4407814 [Escherichia coli]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKRLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT188317 NZ_CP090398:c5376524-5376282 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454ABD6

Antitoxin

Source ID Structure
AlphaFold DB A0A454ABF5

References