Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3171507..3172351 Replicon chromosome
Accession NZ_CP068815
Organism Escherichia coli strain RIVM_C028620

Toxin (Protein)


Gene name yeeV Uniprot ID B1LJY4
Locus tag JNN49_RS15130 Protein ID WP_000854686.1
Coordinates 3171507..3171890 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A8E0J1S3
Locus tag JNN49_RS15135 Protein ID WP_001285602.1
Coordinates 3171971..3172351 (-) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN49_RS15100 3168183..3168887 + 705 WP_001241673.1 leucyl/phenylalanyl-tRNA--protein transferase -
JNN49_RS15105 3169172..3169390 + 219 WP_001040187.1 translation initiation factor IF-1 -
JNN49_RS15115 3169881..3170723 - 843 WP_001431817.1 DUF4942 domain-containing protein -
JNN49_RS15120 3170808..3171005 - 198 WP_000839253.1 DUF957 domain-containing protein -
JNN49_RS15125 3171022..3171510 - 489 WP_001054233.1 hypothetical protein -
JNN49_RS15130 3171507..3171890 - 384 WP_000854686.1 TA system toxin CbtA family protein Toxin
JNN49_RS15135 3171971..3172351 - 381 WP_001285602.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JNN49_RS15140 3172362..3173045 - 684 WP_000086768.1 hypothetical protein -
JNN49_RS15145 3173064..3173285 - 222 WP_000692298.1 DUF987 domain-containing protein -
JNN49_RS15150 3173348..3173824 - 477 WP_001186726.1 RadC family protein -
JNN49_RS15155 3173840..3174325 - 486 WP_000214307.1 antirestriction protein -
JNN49_RS15160 3174417..3175235 - 819 WP_001234732.1 DUF945 domain-containing protein -
JNN49_RS15165 3175335..3175568 - 234 WP_001119719.1 DUF905 family protein -
JNN49_RS15170 3175647..3176102 - 456 WP_001504120.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-113)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14272.28 Da        Isoelectric Point: 6.8614

>T188304 WP_000854686.1 NZ_CP068815:c3171890-3171507 [Escherichia coli]
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGAPSSQLINSIDILRARRATGLMTRDNYRMVNNITLGKHPEEAKQ

Download         Length: 384 bp

>T188304 NZ_CP090397:c4704904-4704620 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13938.69 Da        Isoelectric Point: 5.0823

>AT188304 WP_001285602.1 NZ_CP068815:c3172351-3171971 [Escherichia coli]
VSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Download         Length: 381 bp

>AT188304 NZ_CP090397:c4705136-4704894 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References