Detailed information of TA system TA188280

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4602913..4603733
• Replicon: chromosome
• Accession: NZ_CP068814
• Organism: Escherichia coli strain RIVM_C028613

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: A0A0V9MKL8
• Locus tag: JNN56_RS22185
• Protein ID: WP_001550554.1
• Coordinates: 4602913..4603170 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: JNN56_RS22190
• Protein ID: WP_001519303.1
• Coordinates: 4603182..4603733 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JNN56_RS22160	4599887..4600612	-	726	WP_000066559.1	type 1 fimbria chaperone FimC	-
JNN56_RS22165	4600649..4601146	-	498	WP_000457576.1	type 1 fimbrial protein	-
JNN56_RS22170	4601218..4601915	+	698	Protein_4340	IS1 family transposase	-
JNN56_RS22175	4601932..4602153	-	222	Protein_4341	hypothetical protein	-
JNN56_RS22180	4602237..4602536	+	300	WP_001519304.1	GNAT family N-acetyltransferase	-
JNN56_RS22185	4602913..4603170	+	258	WP_001550554.1	hypothetical protein	Toxin
JNN56_RS22190	4603182..4603733	+	552	WP_001519303.1	N-acetyltransferase	Antitoxin
JNN56_RS22195	4603785..4603946	+	162	WP_001519302.1	hypothetical protein	-
JNN56_RS22200	4603983..4604531	+	549	WP_001519301.1	hypothetical protein	-
JNN56_RS22205	4604658..4604918	+	261	WP_000084876.1	hypothetical protein	-
JNN56_RS22210	4604956..4605072	+	117	Protein_4348	VOC family protein	-
JNN56_RS22215	4605317..4606438	+	1122	WP_000010833.1	M42 family metallopeptidase	-
JNN56_RS22220	4606435..4606713	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
JNN56_RS22225	4606725..4608038	+	1314	WP_001519300.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	4601412..4601915	503

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9744.33 Da
• Isoelectric Point: 11.0090

>T188280 WP_001550554.1 NZ_CP068814:4602913-4603170 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKPVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T188280 NZ_CP068814:4602913-4603170 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGCCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20463.61 Da
• Isoelectric Point: 6.8758

>AT188280 WP_001519303.1 NZ_CP068814:4603182-4603733 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT188280 NZ_CP068814:4603182-4603733 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCGACCTTCAAAGGAGAAATGGATTCACCGCTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA

Structures

Toxin

• AlphaFold DB: A0A0V9MKL8