Detailed information of TA system TA188256

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 889121..889955
• Replicon: chromosome
• Accession: NZ_CP068814
• Organism: Escherichia coli strain RIVM_C028613

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A8E0IX31
• Locus tag: JNN56_RS04205
• Protein ID: WP_000854689.1
• Coordinates: 889121..889498 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A8E0IVP8
• Locus tag: JNN56_RS04210
• Protein ID: WP_001285599.1
• Coordinates: 889575..889955 (-)
• Length: 127 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JNN56_RS04175	885515..885670	-	156	WP_000729638.1	hypothetical protein	-
JNN56_RS04180	886102..887035	-	934	Protein_822	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
JNN56_RS04185	887028..887423	-	396	WP_000208382.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	-
JNN56_RS04190	887492..888337	-	846	WP_001530851.1	DUF4942 domain-containing protein	-
JNN56_RS04195	888422..888619	-	198	WP_000839250.1	DUF957 domain-containing protein	-
JNN56_RS04200	888636..889124	-	489	WP_000761698.1	hypothetical protein	-
JNN56_RS04205	889121..889498	-	378	WP_000854689.1	TA system toxin CbtA family protein	Toxin
JNN56_RS04210	889575..889955	-	381	WP_001285599.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
JNN56_RS04215	890005..890649	-	645	WP_000086757.1	hypothetical protein	-
JNN56_RS04220	890668..890889	-	222	WP_000692315.1	DUF987 domain-containing protein	-
JNN56_RS04225	890954..891430	-	477	WP_001186727.1	RadC family protein	-
JNN56_RS04230	891446..891919	-	474	WP_001538139.1	antirestriction protein	-
JNN56_RS04235	892183..893004	-	822	WP_173009496.1	DUF945 domain-containing protein	-
JNN56_RS04240	893105..893314	-	210	Protein_834	DUF905 family protein	-
JNN56_RS04245	893415..893870	-	456	WP_005051844.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	kpsM / kpsT / kpsS / kpsC / kpsU / kpsD / kpsE / kpsF	867137..890649	23512

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14042.07 Da
• Isoelectric Point: 9.1510

>T188256 WP_000854689.1 NZ_CP068814:c889498-889121 [Escherichia coli]
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Nucleotide

• Length: 378 bp

>T188256 NZ_CP090386:c958249-957962 [Vibrio cholerae]
ATGAAAGTAGTTTGGTCACCTCTAGCGTTACAAAAACTGGGTGATGCCGCAGAGTTTATTGCTTTTGATAACCCATCAGC
TGCAGAAAAGTGGGTGAATGAAGTATTCGACAAAACGGAATTGCTCGGCTCAATGCCAGAAATGGGCCGCATGGTTCCTG
AAATGCCTCATACGAACTACCGTGAAATAATTTTTGGTCATTACCGCATTATTTATAGTTTGAGCCACGAAATCCGCGTT
CTAACAGTTCGTAACTGTCGTCAATTGCTCACGGAACATGATGTGTGA

Antitoxin

Protein

• Length: 127 a.a.
• Molecular weight: 13984.78 Da
• Isoelectric Point: 5.0823

>AT188256 WP_001285599.1 NZ_CP068814:c889955-889575 [Escherichia coli]
MSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLLQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Nucleotide

• Length: 381 bp

>AT188256 NZ_CP090386:c958527-958246 [Vibrio cholerae]
ATGAGCCGTATTCACCTTGATCAAGATATTCAGCCTTTGTCTGAGTTCCGTGCTGGCGTTGCATCATTTATCAAACAGAT
CAATGAGACTCGTCGGCCATTGGTTATTACACAACGAGGTAAAGGTGTAGCCGTTGTTCTTGACGTTGCGGAGTATGAAG
CAATGCAAGAGAAAATCGAATTACTCGAAGAAATGCGTACTGCAGAAGCTCAATTGGCTGCAGGTTTAGGTATATCAAAC
GAAGATGCTCGTTCACAAGTTCTGGGGCGCATCATCAAATGA