Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4634727..4635322 Replicon chromosome
Accession NZ_CP068813
Organism Escherichia coli strain RIVM_C029033

Toxin (Protein)


Gene name chpB Uniprot ID A0A0V9NWK6
Locus tag JNN62_RS22355 Protein ID WP_019842229.1
Coordinates 4634727..4635077 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag JNN62_RS22360 Protein ID WP_001223213.1
Coordinates 4635071..4635322 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN62_RS22335 4630057..4631079 - 1023 WP_001550507.1 ABC transporter permease -
JNN62_RS22340 4631093..4632595 - 1503 WP_001550506.1 sugar ABC transporter ATP-binding protein -
JNN62_RS22345 4632727..4633683 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
JNN62_RS22350 4633993..4634523 + 531 WP_000055075.1 inorganic diphosphatase -
JNN62_RS22355 4634727..4635077 - 351 WP_019842229.1 endoribonuclease toxin ChpB Toxin
JNN62_RS22360 4635071..4635322 - 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
JNN62_RS22365 4635534..4635875 - 342 WP_001550504.1 gamma-glutamylcyclotransferase -
JNN62_RS22370 4635878..4639657 - 3780 WP_001550503.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-115)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12483.44 Da        Isoelectric Point: 5.6097

>T188250 WP_019842229.1 NZ_CP068813:c4635077-4634727 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVWMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

>T188250 NZ_CP090382:c2772866-2772573 [Acinetobacter towneri]
ATGACTTATAATCTTTTACGTCACAAGGACTTCACTGCAGAATGGGAAAAGCTTCCGAGTGCTATACGCGATCAATTCAA
GAAAAAATTAGCTAAGGTAATAGAGCAACCACATATTCCAAAGAATATGCTTAAAGGTGATCTTGCAGGCTGCTATAAAA
TAAAATTATTAAAAGCTGGTGTCCGACTTGTTTACCAGGTCAAAGATGATCAGGTAGTTATTTTGCTAATTACCGTTGGA
AAACGAGCTGATAGCATTGTTTATGATGAAGCAAAAAAGCGGATAAAAGACTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT188250 WP_001223213.1 NZ_CP068813:c4635322-4635071 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT188250 NZ_CP090382:c2773101-2772856 [Acinetobacter towneri]
ATGGCTACTGTTAATTTCAGGGTCGATGAAGCCCTTAAAGAAAAGTCTTATTCCATCCTAAAAGAACAAGGAATTGCACC
TACTGAGTTCTTTACTAATATTCTTGAATATATTGCTACGACTGGAAAGCTTCCAGTACAAAAAGCTTTACTCTCAGAAG
AGGATACCGAGCTATTAGCGATTGTTCGTAAACGTGTTAATGATCCTAAAGAGATGTTCGAGGAAGTCACATTAGATGAC
TTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V9NWK6

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References