Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3569478..3570000 Replicon chromosome
Accession NZ_CP068812
Organism Escherichia coli strain RIVM_C029020

Toxin (Protein)


Gene name relE Uniprot ID A0A829L6G8
Locus tag JNN61_RS16965 Protein ID WP_001105433.1
Coordinates 3569710..3570000 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SC69
Locus tag JNN61_RS16960 Protein ID WP_000212715.1
Coordinates 3569478..3569720 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN61_RS16940 3565197..3566570 + 1374 WP_001522402.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -
JNN61_RS16945 3566720..3567271 - 552 WP_000166270.1 ribosome-associated protein -
JNN61_RS16950 3567365..3568717 + 1353 WP_001162173.1 metalloprotease PmbA -
JNN61_RS16955 3568900..3569286 + 387 WP_001232246.1 cytochrome b562 -
JNN61_RS16960 3569478..3569720 + 243 WP_000212715.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JNN61_RS16965 3569710..3570000 + 291 WP_001105433.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JNN61_RS16970 3570001..3570465 - 465 WP_001009182.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JNN61_RS16975 3570645..3572783 - 2139 WP_000187798.1 anaerobic ribonucleoside-triphosphate reductase -
JNN61_RS16980 3573177..3574832 - 1656 WP_001550509.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11367.23 Da        Isoelectric Point: 10.0238

>T188217 WP_001105433.1 NZ_CP068812:3569710-3570000 [Escherichia coli]
MNYELAFDPRALKEWQKLGVTVREQFKKKLEDVLKRPRNPSAKLRDLPDCYKIKLRTQGYRLVYQVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

>T188217 NZ_CP090365:c1141187-1140888 [Photobacterium sp. TLY01]
ATGGCTGAAATAATCTGGACGGAACCAGCGTTATCTGATCTTAACGAGATTGCTGAATATATAGCCCTTGAAAATACTGT
CGCTGCCAAAGAACTGGTTCAAACCATTTTTGCAAAAGTTGAACGCCTGGAAACCTTCCCGGAATCAGGACGTGTACCGC
CTGAACTGGATTATTTAAATTACCGTGAAATCGTGATTAATCCCTGCCGTATTTTCTACAAGTATGAGGCTGAAAAAGTG
TATATCTTGTTTGTCATGCGAGTAGAAAGAGACTTACGCCGCTTCTTATTAAGAAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9125.56 Da        Isoelectric Point: 5.1369

>AT188217 WP_000212715.1 NZ_CP068812:3569478-3569720 [Escherichia coli]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp

>AT188217 NZ_CP090365:c1141432-1141175 [Photobacterium sp. TLY01]
ATGAAAGTTGAACTGGTTACATCACTGAAGCGCCAAGCGACGAAGATCCTTGCTGATCTTCATGAAACAAAAGAGCCAGT
GCTGATTACTGAGCACGGTAAGCCGTCAGCTTATCTCGTTGATGTTGATGATTATGAATTTATGCAAAATCGTTTAGCAA
TCCTTGAAGGGATCGCTCGAGGAGAGCGCGCATTAGCGGACGGTAAGAGTGTGAGTCATGATGGAGCGAAGGACAGAATG
TCAAAATGGCTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829L6G8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H4B3

References