Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1964348..1965179 Replicon chromosome
Accession NZ_CP068811
Organism Escherichia coli strain RIVM_C028568

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag JNN42_RS09285 Protein ID WP_000854814.1
Coordinates 1964348..1964722 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag JNN42_RS09290 Protein ID WP_001285585.1
Coordinates 1964811..1965179 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN42_RS09245 1959744..1960910 + 1167 WP_000830156.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
JNN42_RS09250 1961029..1961502 + 474 WP_001105415.1 DNA gyrase inhibitor SbmC -
JNN42_RS09255 1961700..1962758 + 1059 WP_001200891.1 FUSC family protein -
JNN42_RS09260 1962930..1963259 + 330 WP_000450409.1 DUF496 family protein -
JNN42_RS09265 1963360..1963542 - 183 WP_001016348.1 hypothetical protein -
JNN42_RS09270 1963614..1963742 + 129 Protein_1813 transposase domain-containing protein -
JNN42_RS09275 1964031..1964144 - 114 WP_001161660.1 DUF957 domain-containing protein -
JNN42_RS09280 1964157..1964351 - 195 WP_000988600.1 hypothetical protein -
JNN42_RS09285 1964348..1964722 - 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
JNN42_RS09290 1964811..1965179 - 369 WP_001285585.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
JNN42_RS09295 1965253..1965474 - 222 WP_000692323.1 DUF987 domain-containing protein -
JNN42_RS09300 1965537..1966013 - 477 WP_039267628.1 RadC family protein -
JNN42_RS09305 1966029..1966508 - 480 WP_000860087.1 antirestriction protein -
JNN42_RS09310 1966590..1967408 - 819 WP_060626401.1 DUF945 domain-containing protein -
JNN42_RS09315 1967508..1967741 - 234 WP_001119729.1 DUF905 family protein -
JNN42_RS09320 1967816..1968271 - 456 WP_000581504.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T188167 WP_000854814.1 NZ_CP068811:c1964722-1964348 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T188167 NZ_CP090316:c1951235-1950933 [Xylella fastidiosa subsp. morus]
ATGGAGAAAGGCACACCCCACTACAAGCTACCAGTCGTCAAAGCCTTGGTGAAAGCTGGCAAGGTCAGGGCTACAGCGAC
CGCCTACCAAGGAGCACGTGAGCTTGGCATCAAAGATTTAACTGGAATGTGCGCCGTTGTCTTGGCGCTCACGTCTGCCG
ACTTCTACAAGAGTATGACGACCTACACGGATCACACATTATTCCAGGATGTGTACCACGCCAAGACGGCAAGCGGTGAT
GAGGTGTACCTGAAGTTAACTGTCATTGATGACGTGTTGATTGTTTCCTTCAAGGAGTTATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT188167 WP_001285585.1 NZ_CP068811:c1965179-1964811 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT188167 NZ_CP090316:c1951598-1951323 [Xylella fastidiosa subsp. morus]
ATGAAACGTATGCACAATCCCGCACATCCAGGTGAAGTGTTGCGTGAGTATCTTGGTGAGCTCACTGTGACCAATGCGGC
TGCAAAGCTAGGCGTCAGCCGTGTGGCTTTGTCGCGTATTCTCAATGGTACCAATGGCATCTCTGCCGATATGGCCCTTC
GCCTGGAAGATGCGCTTGGCACCAGTGCAGAGATGTGGGCAGCCATGCAGTTCAAGTATGACCTGTGGGTTGCTAGTCAG
CAGCCACGCCCGAAGATCACGCGCCTTCATGTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References