Detailed information of TA system TA188127

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 4378881..4379716
• Replicon: chromosome
• Accession: NZ_CP068809
• Organism: Escherichia coli strain RIVM_C028497

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: Q1R2L4
• Locus tag: JNN39_RS20965
• Protein ID: WP_001094426.1
• Coordinates: 4378881..4379258 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: Q1R2L5
• Locus tag: JNN39_RS20970
• Protein ID: WP_001285575.1
• Coordinates: 4379348..4379716 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JNN39_RS20945	4374384..4374563	+	180	WP_001298063.1	hypothetical protein	-
JNN39_RS20950	4374962..4376998	-	2037	WP_000417001.1	hypothetical protein	-
JNN39_RS24260	4377950..4378108	-	159	WP_001467148.1	hypothetical protein	-
JNN39_RS20955	4378187..4378384	-	198	WP_000839272.1	DUF957 domain-containing protein	-
JNN39_RS20960	4378396..4378884	-	489	WP_000761683.1	hypothetical protein	-
JNN39_RS20965	4378881..4379258	-	378	WP_001094426.1	TA system toxin CbtA family protein	Toxin
JNN39_RS20970	4379348..4379716	-	369	WP_001285575.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
JNN39_RS20975	4379796..4380017	-	222	WP_000692350.1	DUF987 domain-containing protein	-
JNN39_RS20980	4380104..4380580	-	477	WP_001298074.1	RadC family protein	-
JNN39_RS20985	4380595..4381080	-	486	WP_000213697.1	antirestriction protein	-
JNN39_RS20990	4381171..4381989	-	819	WP_001175160.1	DUF945 domain-containing protein	-
JNN39_RS20995	4382079..4382312	-	234	WP_001278290.1	DUF905 family protein	-
JNN39_RS21000	4382318..4382995	-	678	WP_001097301.1	hypothetical protein	-
JNN39_RS21005	4383143..4383823	-	681	WP_001282919.1	WYL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14072.99 Da
• Isoelectric Point: 7.3523

>T188127 WP_001094426.1 NZ_CP068809:c4379258-4378881 [Escherichia coli]
MNTLPDTHIREASHCQSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Nucleotide

• Length: 378 bp

>T188127 NZ_CP090304:c3838233-3837748 [Salmonella enterica subsp. enterica serovar Typhimurium]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13709.52 Da
• Isoelectric Point: 6.6258

>AT188127 WP_001285575.1 NZ_CP068809:c4379716-4379348 [Escherichia coli]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKRLTCEADTLGSCGYVYMAVYPTPETKK

Nucleotide

• Length: 369 bp

>AT188127 NZ_CP090304:c3838508-3838221 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Structures

Toxin

• AlphaFold DB: A0A454ABD6

Antitoxin

• AlphaFold DB: A0A454ABF5