Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-HipB |
| Location | 2511594..2513182 | Replicon | chromosome |
| Accession | NZ_CP068809 | ||
| Organism | Escherichia coli strain RIVM_C028497 | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | A0A192ENQ5 |
| Locus tag | JNN39_RS11820 | Protein ID | WP_001125432.1 |
| Coordinates | 2511860..2513182 (+) | Length | 441 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | V0VAH2 |
| Locus tag | JNN39_RS11815 | Protein ID | WP_001304368.1 |
| Coordinates | 2511594..2511860 (+) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JNN39_RS11800 | 2507962..2509413 | + | 1452 | WP_000854642.1 | tagaturonate reductase | - |
| JNN39_RS11805 | 2509610..2510524 | + | 915 | WP_001298637.1 | bestrophin family protein | - |
| JNN39_RS11810 | 2510528..2511286 | - | 759 | WP_001286538.1 | trans-aconitate 2-methyltransferase | - |
| JNN39_RS11815 | 2511594..2511860 | + | 267 | WP_001304368.1 | type II toxin-antitoxin system antitoxin HipB | Antitoxin |
| JNN39_RS11820 | 2511860..2513182 | + | 1323 | WP_001125432.1 | type II toxin-antitoxin system serine/threonine protein kinase toxin HipA | Toxin |
| JNN39_RS11825 | 2513358..2514050 | - | 693 | WP_000382466.1 | hypothetical protein | - |
| JNN39_RS11830 | 2514062..2514337 | - | 276 | WP_000948310.1 | hypothetical protein | - |
| JNN39_RS11835 | 2514339..2514479 | - | 141 | WP_001335097.1 | hypothetical protein | - |
| JNN39_RS11840 | 2514595..2514777 | - | 183 | WP_001335098.1 | hypothetical protein | - |
| JNN39_RS11845 | 2514947..2515999 | + | 1053 | WP_000568119.1 | hypothetical protein | - |
| JNN39_RS11850 | 2516011..2516328 | + | 318 | WP_000073834.1 | hypothetical protein | - |
| JNN39_RS11855 | 2516532..2516774 | + | 243 | WP_000699011.1 | phage capsid protein | - |
| JNN39_RS11860 | 2516821..2518101 | + | 1281 | WP_000823306.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2511576..2530882 | 19306 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 441 a.a. Molecular weight: 49297.02 Da Isoelectric Point: 8.6972
>T188112 WP_001125432.1 NZ_CP068809:2511860-2513182 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTCPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVKRFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIAQIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGIK
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTCPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVKRFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIAQIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGIK
Download Length: 1323 bp
>T188112 NZ_CP090245:c115430-115041 [Klebsiella oxytoca]
ATGCAAAAAATATCATCACACCCGATACGGGCGAATCAGCCCTGCCTGTCACCCATTGAAATCTGGCAGCGATTGCTTAC
TCATCTGTTATCGCAGCATTATGGCCTGACGCTGAATGACACACCGTTCAGTAATGACTCCACCATCCAGGAGCATATTG
ATGCCGGAGTATCGCTCAGCGATGCGGTGAACTTTCTTGTCGAAAAATATGAACTGGAAAGAATTGACCGCGATGGTTGC
ACTGTCATGGAAAAGTCACCGTTTATTACCAGTATCGATATTCTACGTGCCCGTAAGGCCTCAGGCCTAATGAAACGCAG
CAGTCACAAAACTGTTACCCGGGTAACGGCAGGCCATCATCAGCAGCTAAAAATCACTAAGGGTACTTAA
ATGCAAAAAATATCATCACACCCGATACGGGCGAATCAGCCCTGCCTGTCACCCATTGAAATCTGGCAGCGATTGCTTAC
TCATCTGTTATCGCAGCATTATGGCCTGACGCTGAATGACACACCGTTCAGTAATGACTCCACCATCCAGGAGCATATTG
ATGCCGGAGTATCGCTCAGCGATGCGGTGAACTTTCTTGTCGAAAAATATGAACTGGAAAGAATTGACCGCGATGGTTGC
ACTGTCATGGAAAAGTCACCGTTTATTACCAGTATCGATATTCTACGTGCCCGTAAGGCCTCAGGCCTAATGAAACGCAG
CAGTCACAAAACTGTTACCCGGGTAACGGCAGGCCATCATCAGCAGCTAAAAATCACTAAGGGTACTTAA
Antitoxin
Download Length: 89 a.a. Molecular weight: 9957.31 Da Isoelectric Point: 4.9632
>AT188112 WP_001304368.1 NZ_CP068809:2511594-2511860 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTSLTTFFKILQSLELSMTLCDAKNASPEA
AEQQDLEW
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTSLTTFFKILQSLELSMTLCDAKNASPEA
AEQQDLEW
Download Length: 267 bp
>AT188112 NZ_CP090245:c115834-115469 [Klebsiella oxytoca]
ATGAATAATCACTCAGAATCCGGTACCACGCCGGAGAATCCTACCTGCCAGCAGTGGGGACTAAAGAGCACGATCACACC
CTGTTTTGGCGCTCGTCTGGTGCAGGAAGACTGCCGGATACATTTTCTCGCTGACCGGGCCGGATTCAACGGTGCTTTCA
GTGACAACGATACATTGCGCCTCGACCAAGCCTTTCCGTTGATGCTCAAACAACTGGAGTTGATGCTGACTAGCGGCGAG
CTCAATCCCCGCTATCAGCACTGCGTCACGCTTTACCACAACGGACTCACCTGCGAAGCCGACACACTCGGTTCCTGTGG
CTATGTCTACATTGCTATCTATCCTGAGCAGACTGAGCCGCAGTAA
ATGAATAATCACTCAGAATCCGGTACCACGCCGGAGAATCCTACCTGCCAGCAGTGGGGACTAAAGAGCACGATCACACC
CTGTTTTGGCGCTCGTCTGGTGCAGGAAGACTGCCGGATACATTTTCTCGCTGACCGGGCCGGATTCAACGGTGCTTTCA
GTGACAACGATACATTGCGCCTCGACCAAGCCTTTCCGTTGATGCTCAAACAACTGGAGTTGATGCTGACTAGCGGCGAG
CTCAATCCCCGCTATCAGCACTGCGTCACGCTTTACCACAACGGACTCACCTGCGAAGCCGACACACTCGGTTCCTGTGG
CTATGTCTACATTGCTATCTATCCTGAGCAGACTGAGCCGCAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A192ENQ5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | V0VAH2 |