Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4434894..4435402 Replicon chromosome
Accession NZ_CP068808
Organism Escherichia coli strain RIVM_C018699

Toxin (Protein)


Gene name shpA Uniprot ID -
Locus tag JNN47_RS21450 Protein ID WP_001534843.1
Coordinates 4435193..4435402 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A0V9L4L3
Locus tag JNN47_RS21445 Protein ID WP_000063161.1
Coordinates 4434894..4435196 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN47_RS21430 4431422..4433572 + 2151 WP_001366791.1 pyruvate/proton symporter BtsT -
JNN47_RS21435 4433690..4433893 + 204 WP_001534846.1 YbdD/YjiX family protein -
JNN47_RS21440 4433904..4434860 + 957 WP_001534845.1 GTPase -
JNN47_RS21445 4434894..4435196 - 303 WP_000063161.1 BrnA antitoxin family protein Antitoxin
JNN47_RS21450 4435193..4435402 - 210 WP_001534843.1 BrnT family toxin Toxin
JNN47_RS21455 4435498..4436664 + 1167 WP_001534841.1 restriction endonuclease -
JNN47_RS21460 4436728..4438347 + 1620 WP_001550561.1 type I restriction-modification system subunit M -
JNN47_RS21465 4438337..4439647 + 1311 WP_001534837.1 restriction endonuclease subunit S -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7952.17 Da        Isoelectric Point: 4.9493

>T188089 WP_001534843.1 NZ_CP068808:c4435402-4435193 [Escherichia coli]
MVDYPKRDAISNINAIIVDTFLYIQLGMATMPMEFEWNANKAKSNRVKHGIRFEDAVLVLDDPQRTEPL

Download         Length: 210 bp

>T188089 NZ_CP090242:326163-326265 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11600.10 Da        Isoelectric Point: 9.4646

>AT188089 WP_000063161.1 NZ_CP068808:c4435196-4434894 [Escherichia coli]
MSMVKHKRGTSSTLDVQHEAELKVLANKFDEDIDYSDIPSSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp

>AT188089 NZ_CP090242:c326272-326127 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0V9L4L3

References