Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 876113..876945 Replicon chromosome
Accession NZ_CP068808
Organism Escherichia coli strain RIVM_C018699

Toxin (Protein)


Gene name yeeV Uniprot ID A0A3P5UBZ5
Locus tag JNN47_RS04165 Protein ID WP_001094454.1
Coordinates 876113..876487 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A3G8RJV8
Locus tag JNN47_RS04170 Protein ID WP_001320394.1
Coordinates 876577..876945 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN47_RS04135 871226..872374 - 1149 WP_000905922.1 capsule polysaccharide export inner-membrane protein KpsE -
JNN47_RS04140 872446..873429 - 984 WP_001298261.1 KpsF/GutQ family sugar-phosphate isomerase -
JNN47_RS04145 874240..874410 - 171 Protein_813 IS110 family transposase -
JNN47_RS04150 874753..875322 - 570 WP_001290250.1 DUF4942 domain-containing protein -
JNN47_RS04155 875419..875616 - 198 WP_000839276.1 DUF957 domain-containing protein -
JNN47_RS04160 875628..876116 - 489 WP_000777545.1 hypothetical protein -
JNN47_RS04165 876113..876487 - 375 WP_001094454.1 TA system toxin CbtA family protein Toxin
JNN47_RS04170 876577..876945 - 369 WP_001320394.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JNN47_RS04175 876995..877638 - 644 Protein_819 antitoxin of toxin-antitoxin stability system -
JNN47_RS04180 877657..877878 - 222 WP_000692300.1 DUF987 domain-containing protein -
JNN47_RS04185 877941..878417 - 477 WP_001186726.1 RadC family protein -
JNN47_RS04190 878433..878918 - 486 WP_029701480.1 antirestriction protein -
JNN47_RS04195 878973..879791 - 819 WP_001234642.1 DUF945 domain-containing protein -
JNN47_RS04200 879891..880124 - 234 WP_001119719.1 DUF905 family protein -
JNN47_RS04205 880203..880658 - 456 WP_000581493.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14059.10 Da        Isoelectric Point: 9.2447

>T188068 WP_001094454.1 NZ_CP068808:c876487-876113 [Escherichia coli]
MNTLPDTHVRKASRCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T188068 NZ_CP090218:1920902-1921004 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13623.22 Da        Isoelectric Point: 6.4783

>AT188068 WP_001320394.1 NZ_CP068808:c876945-876577 [Escherichia coli]
VSDTFSGTTHPDDNHDRPWWGLPSTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADANHLDQAFPLLMKQLELMFTSS
ELNPHRQNTVTLYAKGLTCHADTLGSCGYVYLAVYPTPETKQ

Download         Length: 369 bp

>AT188068 NZ_CP090218:c1921011-1920866 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3P5UBZ5

Antitoxin

Source ID Structure
AlphaFold DB A0A3G8RJV8

References