Detailed information of TA system TA188057

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 3759148..3759968
• Replicon: chromosome
• Accession: NZ_CP068807
• Organism: Escherichia coli strain RIVM_C018583

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: A0A0V9MKL8
• Locus tag: JNN51_RS18055
• Protein ID: WP_001550554.1
• Coordinates: 3759711..3759968 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: JNN51_RS18050
• Protein ID: WP_001519303.1
• Coordinates: 3759148..3759699 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JNN51_RS18015	3754843..3756156	-	1314	WP_001519300.1	galactitol-specific PTS transporter subunit IIC	-
JNN51_RS18020	3756168..3756446	-	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
JNN51_RS18025	3756443..3757564	-	1122	WP_000010833.1	M42 family metallopeptidase	-
JNN51_RS18030	3757809..3757925	-	117	Protein_3517	VOC family protein	-
JNN51_RS18035	3757963..3758223	-	261	WP_000084876.1	hypothetical protein	-
JNN51_RS18040	3758350..3758898	-	549	WP_001519301.1	hypothetical protein	-
JNN51_RS18045	3758935..3759096	-	162	WP_001519302.1	hypothetical protein	-
JNN51_RS18050	3759148..3759699	-	552	WP_001519303.1	N-acetyltransferase	Antitoxin
JNN51_RS18055	3759711..3759968	-	258	WP_001550554.1	hypothetical protein	Toxin
JNN51_RS18060	3760345..3760644	-	300	WP_001519304.1	GNAT family N-acetyltransferase	-
JNN51_RS18065	3760728..3760949	+	222	Protein_3524	hypothetical protein	-
JNN51_RS18070	3760966..3761663	-	698	Protein_3525	IS1 family transposase	-
JNN51_RS18075	3761715..3762725	+	1011	Protein_3526	helicase YjhR	-
JNN51_RS18080	3763308..3764288	-	981	WP_001519307.1	transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9744.33 Da
• Isoelectric Point: 11.0090

>T188057 WP_001550554.1 NZ_CP068807:c3759968-3759711 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKPVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T188057 NZ_CP090212:4279886-4280263 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20463.61 Da
• Isoelectric Point: 6.8758

>AT188057 WP_001519303.1 NZ_CP068807:c3759699-3759148 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT188057 NZ_CP090212:4279465-4279839 [Escherichia coli]
GTGTCAGACACACACCCCGGGACAACGCATCCCGACAACAACAACGACCGCCCCTGGTGGGGGCTCCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGGGGGCAGT
TTAGCGACGCGGATGCGTATCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Structures

Toxin

• AlphaFold DB: A0A0V9MKL8