Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 3635881..3636476 Replicon chromosome
Accession NZ_CP068807
Organism Escherichia coli strain RIVM_C018583

Toxin (Protein)


Gene name chpB Uniprot ID A0A0V9NWK6
Locus tag JNN51_RS17430 Protein ID WP_019842229.1
Coordinates 3636126..3636476 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag JNN51_RS17425 Protein ID WP_001223213.1
Coordinates 3635881..3636132 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN51_RS17415 3631546..3635325 + 3780 WP_001550503.1 autotransporter assembly complex protein TamB -
JNN51_RS17420 3635328..3635669 + 342 WP_001550504.1 gamma-glutamylcyclotransferase -
JNN51_RS17425 3635881..3636132 + 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
JNN51_RS17430 3636126..3636476 + 351 WP_019842229.1 endoribonuclease toxin ChpB Toxin
JNN51_RS17435 3636680..3637210 - 531 WP_000055075.1 inorganic diphosphatase -
JNN51_RS17440 3637520..3638476 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
JNN51_RS17445 3638608..3640110 + 1503 WP_001550506.1 sugar ABC transporter ATP-binding protein -
JNN51_RS17450 3640124..3641146 + 1023 WP_001550507.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-115)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12483.44 Da        Isoelectric Point: 5.6097

>T188055 WP_019842229.1 NZ_CP068807:3636126-3636476 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVWMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

>T188055 NZ_CP090212:3519380-3519598 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT188055 WP_001223213.1 NZ_CP068807:3635881-3636132 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT188055 NZ_CP090212:3518980-3519354 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V9NWK6

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References