Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2902450..2903282 Replicon chromosome
Accession NZ_CP068807
Organism Escherichia coli strain RIVM_C018583

Toxin (Protein)


Gene name yeeV Uniprot ID E3PN67
Locus tag JNN51_RS14045 Protein ID WP_000854775.1
Coordinates 2902908..2903282 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A426P7N5
Locus tag JNN51_RS14040 Protein ID WP_001285645.1
Coordinates 2902450..2902818 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN51_RS14005 2898273..2898953 + 681 WP_001282911.1 WYL domain-containing protein -
JNN51_RS14010 2899104..2899781 + 678 WP_001097567.1 hypothetical protein -
JNN51_RS14015 2899787..2900020 + 234 WP_032289278.1 DUF905 family protein -
JNN51_RS14020 2900110..2900928 + 819 WP_001175173.1 DUF945 domain-containing protein -
JNN51_RS14025 2901020..2901505 + 486 WP_000213717.1 antirestriction protein -
JNN51_RS14030 2901521..2901997 + 477 WP_202852312.1 RadC family protein -
JNN51_RS14035 2902066..2902287 + 222 WP_000692303.1 DUF987 domain-containing protein -
JNN51_RS14040 2902450..2902818 + 369 WP_001285645.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JNN51_RS14045 2902908..2903282 + 375 WP_000854775.1 TA system toxin CbtA family protein Toxin
JNN51_RS14050 2903279..2903770 + 492 WP_000976825.1 hypothetical protein -
JNN51_RS14055 2903782..2903979 + 198 WP_000772035.1 DUF957 domain-containing protein -
JNN51_RS14060 2904064..2904906 + 843 WP_001274548.1 DUF4942 domain-containing protein -
JNN51_RS14065 2905090..2905272 + 183 WP_177309578.1 hypothetical protein -
JNN51_RS14070 2905700..2906884 + 1185 WP_001172876.1 sugar efflux transporter -
JNN51_RS14075 2906995..2907918 + 924 WP_000535949.1 carboxylate/amino acid/amine transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13965.02 Da        Isoelectric Point: 8.2830

>T188051 WP_000854775.1 NZ_CP068807:2902908-2903282 [Escherichia coli]
MKTLPDTLVREASRCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAK

Download         Length: 375 bp

>T188051 NZ_CP090212:2110640-2110743 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13678.37 Da        Isoelectric Point: 5.4492

>AT188051 WP_001285645.1 NZ_CP068807:2902450-2902818 [Escherichia coli]
VSDTLSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRADIRGRFSDADAYHLDQAFPLLMKQLELMLTNG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT188051 NZ_CP090212:c2110781-2110510 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E3PN67

Antitoxin

Source ID Structure
AlphaFold DB A0A426P7N5

References