Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 956688..957519 Replicon chromosome
Accession NZ_CP068807
Organism Escherichia coli strain RIVM_C018583

Toxin (Protein)


Gene name yeeV Uniprot ID A0A6C9I6Z5
Locus tag JNN51_RS04805 Protein ID WP_001563930.1
Coordinates 957145..957519 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag JNN51_RS04800 Protein ID WP_001285585.1
Coordinates 956688..957056 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN51_RS04770 953577..954032 + 456 WP_000581502.1 hypothetical protein -
JNN51_RS04775 954111..954344 + 234 WP_001119729.1 DUF905 family protein -
JNN51_RS04780 954444..955262 + 819 WP_202852339.1 DUF945 domain-containing protein -
JNN51_RS04785 955353..955838 + 486 WP_000214393.1 antirestriction protein -
JNN51_RS04790 955854..956330 + 477 WP_023910200.1 RadC family protein -
JNN51_RS04795 956393..956614 + 222 WP_000692323.1 DUF987 domain-containing protein -
JNN51_RS04800 956688..957056 + 369 WP_001285585.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
JNN51_RS04805 957145..957519 + 375 WP_001563930.1 type IV toxin-antitoxin system toxin CbtA Toxin
JNN51_RS04810 957516..957710 + 195 WP_000988600.1 hypothetical protein -
JNN51_RS04815 957723..957836 + 114 WP_001161660.1 DUF957 domain-containing protein -
JNN51_RS04820 958125..958253 - 129 Protein_946 transposase domain-containing protein -
JNN51_RS04825 958325..958507 + 183 WP_001016348.1 hypothetical protein -
JNN51_RS04830 958608..958937 - 330 WP_000450409.1 DUF496 family protein -
JNN51_RS04835 959109..960167 - 1059 WP_001200891.1 FUSC family protein -
JNN51_RS04840 960365..960838 - 474 WP_001105415.1 DNA gyrase inhibitor SbmC -
JNN51_RS04845 960957..962123 - 1167 WP_001563931.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13883.97 Da        Isoelectric Point: 7.8522

>T188043 WP_001563930.1 NZ_CP068807:957145-957519 [Escherichia coli]
MKTLPVLPGLAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T188043 NZ_CP090208:473824-474111 [Pantoea agglomerans]
GTGACTTACACAATAAAATTCAGAGAAGAAGCGTTAAAAGAGTGGCTAAAGCTGGATAAAGCCATTCAGCAGCAGTTTGC
AAAGAAACTAAAGAAGTGTTGTGAGCATCCCCATATTCCCACTGCGGCTCTGCGCGGGTTAAAAGACTGTTATAAGATCA
AACTCCGGGCGTCCGGTTTTCGCCTGGTCTATCAGGTCATCGACGATCAACTCATCATTGCGGTGGTTGCAGTAGGGAAA
CGTGAGCGCAGTGAAGTCTACAATCTTGCCAGCAAAAGAATGCGTTAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT188043 WP_001285585.1 NZ_CP068807:956688-957056 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT188043 NZ_CP090208:473576-473827 [Pantoea agglomerans]
ATGCCGCATATTATCCTGAGTGACACCAGTGCCAGCGTCAGCGAACTGAAAAAAAACCCGATGGCGACCGTTAATGCTGG
TGAGGGTTATCCTGTCGCCATTCTTAATCGCAATCAGCCCGCTTTTTACTGTGTGCCTGCGGAGTTATATGAGCAGATAC
TCGATGCGCTGGACGATAGTGAACTGGTAAAGCTGGTTAACCAACGTAGCCAGCAGAAGCTGATTGACGTCGATCTGGAC
GATTTTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C9I6Z5

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References