188024

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3959450..3960104 Replicon chromosome
Accession NZ_CP068806
Organism Escherichia coli strain RIVM_C018576

Toxin (Protein)


Gene name cptA Uniprot ID B7N7E0
Locus tag JNN57_RS18965 Protein ID WP_000244769.1
Coordinates 3959450..3959857 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag JNN57_RS18970 Protein ID WP_000354046.1
Coordinates 3959838..3960104 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN57_RS18945 3955407..3957140 - 1734 WP_000813190.1 single-stranded-DNA-specific exonuclease RecJ -
JNN57_RS18950 3957146..3957856 - 711 WP_000715210.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JNN57_RS18955 3957881..3958777 - 897 WP_000806652.1 site-specific tyrosine recombinase XerD -
JNN57_RS18960 3958889..3959410 + 522 WP_001055874.1 flavodoxin FldB -
JNN57_RS18965 3959450..3959857 - 408 WP_000244769.1 protein YgfX Toxin
JNN57_RS18970 3959838..3960104 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
JNN57_RS18975 3960347..3961327 + 981 WP_000886049.1 tRNA-modifying protein YgfZ -
JNN57_RS18980 3961404..3962063 - 660 WP_000250274.1 hemolysin III family protein -
JNN57_RS18985 3962227..3962538 - 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
JNN57_RS18990 3962583..3964016 + 1434 WP_001513393.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16062.03 Da        Isoelectric Point: 11.5554

>T188024 WP_000244769.1 NZ_CP068806:c3959857-3959450 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGK
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T188024 NZ_CP090203:c3641842-3641558 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT188024 WP_000354046.1 NZ_CP068806:c3960104-3959838 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT188024 NZ_CP090203:c3642074-3641832 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829J3T1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QD57

References