Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4595491..4596086 Replicon chromosome
Accession NZ_CP068805
Organism Escherichia coli strain RIVM_C018567

Toxin (Protein)


Gene name chpB Uniprot ID A0A0V9NWK6
Locus tag JNN55_RS22280 Protein ID WP_019842229.1
Coordinates 4595491..4595841 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag JNN55_RS22285 Protein ID WP_001223213.1
Coordinates 4595835..4596086 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN55_RS22260 4590821..4591843 - 1023 WP_001550507.1 ABC transporter permease -
JNN55_RS22265 4591857..4593359 - 1503 WP_001550506.1 sugar ABC transporter ATP-binding protein -
JNN55_RS22270 4593491..4594447 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
JNN55_RS22275 4594757..4595287 + 531 WP_000055075.1 inorganic diphosphatase -
JNN55_RS22280 4595491..4595841 - 351 WP_019842229.1 endoribonuclease toxin ChpB Toxin
JNN55_RS22285 4595835..4596086 - 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
JNN55_RS22290 4596298..4596639 - 342 WP_001550504.1 gamma-glutamylcyclotransferase -
JNN55_RS22295 4596642..4600421 - 3780 WP_001550503.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-115)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12483.44 Da        Isoelectric Point: 5.6097

>T187993 WP_019842229.1 NZ_CP068805:c4595841-4595491 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVWMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

>T187993 NZ_CP090196:220247-220354 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CATGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT187993 WP_001223213.1 NZ_CP068805:c4596086-4595835 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT187993 NZ_CP090196:c220198-220135 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V9NWK6

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References