Detailed information of TA system TA187991

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4476672..4477492
• Replicon: chromosome
• Accession: NZ_CP068805
• Organism: Escherichia coli strain RIVM_C018567

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: A0A0V9MKL8
• Locus tag: JNN55_RS21690
• Protein ID: WP_001550554.1
• Coordinates: 4476672..4476929 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: JNN55_RS21695
• Protein ID: WP_001519303.1
• Coordinates: 4476941..4477492 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JNN55_RS21670	4471958..4473064	+	1107	WP_001519308.1	N-acetylneuraminate epimerase	-
JNN55_RS21675	4473129..4474109	+	981	WP_001519307.1	transposase	-
JNN55_RS21680	4474692..4475933	-	1242	Protein_4245	helicase YjhR	-
JNN55_RS21685	4475996..4476295	+	300	WP_001519304.1	GNAT family N-acetyltransferase	-
JNN55_RS21690	4476672..4476929	+	258	WP_001550554.1	hypothetical protein	Toxin
JNN55_RS21695	4476941..4477492	+	552	WP_001519303.1	N-acetyltransferase	Antitoxin
JNN55_RS21700	4477544..4477705	+	162	WP_001519302.1	hypothetical protein	-
JNN55_RS21705	4477742..4478290	+	549	WP_001519301.1	hypothetical protein	-
JNN55_RS21710	4478417..4478677	+	261	WP_000084876.1	hypothetical protein	-
JNN55_RS21715	4478715..4478831	+	117	Protein_4252	VOC family protein	-
JNN55_RS21720	4479076..4480197	+	1122	WP_000010833.1	M42 family metallopeptidase	-
JNN55_RS21725	4480194..4480472	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
JNN55_RS21730	4480484..4481797	+	1314	WP_001519300.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimB	4469156..4477705	8549

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9744.33 Da
• Isoelectric Point: 11.0090

>T187991 WP_001550554.1 NZ_CP068805:4476672-4476929 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKPVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T187991 NZ_CP090196:219280-219387 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGCATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20463.61 Da
• Isoelectric Point: 6.8758

>AT187991 WP_001519303.1 NZ_CP068805:4476941-4477492 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT187991 NZ_CP090196:c219222-219168 [Escherichia coli]
CAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Structures

Toxin

• AlphaFold DB: A0A0V9MKL8