Detailed information of TA system TA187986

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-HTH_XRE
• Location: 3396946..3397651
• Replicon: chromosome
• Accession: NZ_CP068805
• Organism: Escherichia coli strain RIVM_C018567

Toxin (Protein)

• Gene name: relE
• Uniprot ID: S1F406
• Locus tag: JNN55_RS16555
• Protein ID: WP_000539521.1
• Coordinates: 3396946..3397332 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: JNN55_RS16560
• Protein ID: WP_001280945.1
• Coordinates: 3397322..3397651 (+)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JNN55_RS16535	3392950..3393576	+	627	WP_001295292.1	glutathione S-transferase GstB	-
JNN55_RS16540	3393573..3394688	-	1116	WP_000555051.1	aldose sugar dehydrogenase YliI	-
JNN55_RS16545	3394799..3395182	-	384	WP_000497137.1	biofilm formation regulator BssR	-
JNN55_RS16550	3395395..3396720	+	1326	WP_000049367.1	30S ribosomal protein S12 methylthiotransferase RimO	-
JNN55_RS16555	3396946..3397332	+	387	WP_000539521.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JNN55_RS16560	3397322..3397651	+	330	WP_001280945.1	DNA-binding transcriptional regulator	Antitoxin
JNN55_RS16565	3397721..3399049	-	1329	WP_001550887.1	GGDEF domain-containing protein	-
JNN55_RS16570	3399057..3401405	-	2349	WP_001550886.1	EAL domain-containing protein	-
JNN55_RS16575	3401583..3402494	-	912	WP_001236042.1	glutathione ABC transporter permease GsiD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-124)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-94)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14293.45 Da
• Isoelectric Point: 9.9296

>T187986 WP_000539521.1 NZ_CP068805:3396946-3397332 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Nucleotide

• Length: 387 bp

>T187986 NZ_CP090192:c2722160-2722057 [Enterobacter hormaechei]
GGCAAGGCGATTGAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 11982.08 Da
• Isoelectric Point: 10.0101

>AT187986 WP_001280945.1 NZ_CP068805:3397322-3397651 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Nucleotide

• Length: 330 bp

>AT187986 NZ_CP090192:2722052-2722253 [Enterobacter hormaechei]
CAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTT
GGCATTAATGCAGGCTCAATCGCCTTGCCCTTTAAGAATAGATGACGACGTCAGGTTTTCCAGTCCACAGTAAAAGTGGT
CTGAAAAAAAGCGTCAGAACATCACTAAATGTGAAAAACCGC

Structures

Toxin

• AlphaFold DB: A0A829GCT6