Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2001800..2002631 Replicon chromosome
Accession NZ_CP068805
Organism Escherichia coli strain RIVM_C018567

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag JNN55_RS09610 Protein ID WP_000854814.1
Coordinates 2001800..2002174 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag JNN55_RS09615 Protein ID WP_001285585.1
Coordinates 2002263..2002631 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN55_RS09570 1997196..1998362 + 1167 WP_000830156.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
JNN55_RS09575 1998481..1998954 + 474 WP_001105415.1 DNA gyrase inhibitor SbmC -
JNN55_RS09580 1999152..2000210 + 1059 WP_001200891.1 FUSC family protein -
JNN55_RS09585 2000382..2000711 + 330 WP_000450409.1 DUF496 family protein -
JNN55_RS09590 2000812..2000994 - 183 WP_001016348.1 hypothetical protein -
JNN55_RS09595 2001066..2001194 + 129 Protein_1879 transposase domain-containing protein -
JNN55_RS09600 2001483..2001596 - 114 WP_001161660.1 DUF957 domain-containing protein -
JNN55_RS09605 2001609..2001803 - 195 WP_000988600.1 hypothetical protein -
JNN55_RS09610 2001800..2002174 - 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
JNN55_RS09615 2002263..2002631 - 369 WP_001285585.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
JNN55_RS09620 2002705..2002926 - 222 WP_000692323.1 DUF987 domain-containing protein -
JNN55_RS09625 2002989..2003465 - 477 WP_001186726.1 RadC family protein -
JNN55_RS09630 2003481..2003960 - 480 WP_134259499.1 antirestriction protein -
JNN55_RS09635 2004042..2004860 - 819 WP_001234629.1 DUF945 domain-containing protein -
JNN55_RS09640 2004960..2005193 - 234 WP_001119729.1 DUF905 family protein -
JNN55_RS09645 2005272..2005727 - 456 WP_000581502.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T187974 WP_000854814.1 NZ_CP068805:c2002174-2001800 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T187974 NZ_CP090179:569234-569566 [Vibrio harveyi]
ATGAAAAGTGTATTTGTCGAATCAACCATATTTGAAAAGTACCGTAATGAATATCTCAGCGATGATGAGTTTAGGCTTTT
TCAAGCAGAGTTAATGTCTAACCCGAAGCAGGGTGACGTGATTCAAGGTACAGGTGGTTTGCGAAAGATTCGAGTTGCAA
GTAAAGGTAAGGGCAAGCGTGGTGGCTCTCGCGTTATCTATTACTTCCTCGATGAAAAGCGTCGTTTCTACTTGCTGACG
ATTTACGGCAAGAATGAAATGTCCGACTTAACCGTAGACCAAAAGAAACAACTAAAGGCTTTTATGGAGGCGTGGCGTAA
TGAGCAATCGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT187974 WP_001285585.1 NZ_CP068805:c2002631-2002263 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT187974 NZ_CP090179:569553-569867 [Vibrio harveyi]
ATGAGCAATCGTAATTTATTTGCGGAGTTAAGTTCAGCACTTGTTGAGGCTAAAGAGCATTCAGAGGGCAAGCTTACCCT
TAAAACTCATCAAGTTAACGACATCAGTGAGTTAAATATCTCACCTGATGAAATCGTGAGTATTCGAGAGCAGTTTAATA
TGTCTCGTGGTGTGTTTGCTCGTTTGTTGCACACATCATCTCGTACGTTAGAAAACTGGGAACAAGGGCGTAGCGCACCA
AATGGACAAGCAGTAACTCTTCTAAAGTTGGTTCAGCGTCATCCAGAAACCCTGTCGCACATCGCTGAGCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References