Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 72581..73416 Replicon chromosome
Accession NZ_CP068805
Organism Escherichia coli strain RIVM_C018567

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag JNN55_RS00305 Protein ID WP_001565141.1
Coordinates 72581..72958 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag JNN55_RS00310 Protein ID WP_001565140.1
Coordinates 73048..73416 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN55_RS00275 67948..68871 - 924 WP_000535949.1 carboxylate/amino acid/amine transporter -
JNN55_RS00280 68982..70166 - 1185 WP_001172876.1 sugar efflux transporter -
JNN55_RS00285 70594..70776 - 183 WP_177309578.1 hypothetical protein -
JNN55_RS00290 70960..71802 - 843 WP_001565143.1 DUF4942 domain-containing protein -
JNN55_RS00295 71887..72084 - 198 WP_000839256.1 DUF957 domain-containing protein -
JNN55_RS00300 72096..72584 - 489 WP_001565142.1 hypothetical protein -
JNN55_RS00305 72581..72958 - 378 WP_001565141.1 TA system toxin CbtA family protein Toxin
JNN55_RS00310 73048..73416 - 369 WP_001565140.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JNN55_RS00315 73491..73712 - 222 WP_000692303.1 DUF987 domain-containing protein -
JNN55_RS00320 73781..74257 - 477 WP_001186724.1 RadC family protein -
JNN55_RS00325 74273..74758 - 486 WP_001565139.1 antirestriction protein -
JNN55_RS00330 74850..75668 - 819 WP_021536653.1 DUF945 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14246.27 Da        Isoelectric Point: 7.2920

>T187967 WP_001565141.1 NZ_CP068805:c72958-72581 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SICPRSQLINSIDILRARRATGLMTRDNYRMVNNITQGKHPEAQQ

Download         Length: 378 bp

>T187967 NZ_CP090146:c4767541-4767230 [Enterobacter hormaechei]
ATGCTATTCATTGAAACGGATATTTTTACAGAAGACGTCAAAACGTTACTGGATGACGACGAATATCATAGGTTCCAAAT
ATTCCTGGCAACGCAACCGGATTACGGCGATCTGATCCAGAATACGGGAGGCTTGCGAAAGATTCGCTGGCTTGCTGGCG
GTAAGGGAAAGCGTAGTGGAGTCAGAGTTATCTATTTTCACCGTACGCGTGAGTGTGAAATCAGGTTGCTGCTCATCTAT
CGCAAAGGGATCAAAGATGACCTCTCCGCGGGTGAAAAAGCCATACTGAAAAAGATGATTGAGAGGTGGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13604.41 Da        Isoelectric Point: 6.7389

>AT187967 WP_001565140.1 NZ_CP068805:c73416-73048 [Escherichia coli]
VSDTLPGTTHPDDNHDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFALLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT187967 NZ_CP090146:c4767229-4766939 [Enterobacter hormaechei]
ATGGATAAGGCGCTGTTTGAGCGATTAACCCAAAGCATTGCGCAAATCAACGAAATTGCCGAGGGCCAACGAGAGCCGTC
GCGTACGTTTCAAATTGATGCGATGAAAATAAAAGAAATTCGTCAGGCGTCCGGGTTGTCGCAGAGTAAATTCGCGAACT
TAATCTCAGTTAGCGTTGATACGTTGCGTAACTGGGAACAAGGCAGACGCTCACCTACAGGCCCCGCTAAAGCGCTATTG
CGCGCCATTGCTAACGACCCTCAACATGTCATCCCAGCCCTAACGCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References