Detailed information of TA system TA187962

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4465760..4466580
• Replicon: chromosome
• Accession: NZ_CP068804
• Organism: Escherichia coli strain RIVM_C018563

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: A0A0V9MKL8
• Locus tag: JNN37_RS21465
• Protein ID: WP_001550554.1
• Coordinates: 4465760..4466017 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: JNN37_RS21470
• Protein ID: WP_001519303.1
• Coordinates: 4466029..4466580 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JNN37_RS21445	4461046..4462152	+	1107	WP_001519308.1	N-acetylneuraminate epimerase	-
JNN37_RS21450	4462217..4463197	+	981	WP_001519307.1	transposase	-
JNN37_RS21455	4463780..4465021	-	1242	Protein_4203	helicase YjhR	-
JNN37_RS21460	4465084..4465383	+	300	WP_001519304.1	GNAT family N-acetyltransferase	-
JNN37_RS21465	4465760..4466017	+	258	WP_001550554.1	hypothetical protein	Toxin
JNN37_RS21470	4466029..4466580	+	552	WP_001519303.1	N-acetyltransferase	Antitoxin
JNN37_RS21475	4466632..4466793	+	162	WP_001519302.1	hypothetical protein	-
JNN37_RS21480	4466830..4467378	+	549	WP_001519301.1	hypothetical protein	-
JNN37_RS21485	4467505..4467765	+	261	WP_000084876.1	hypothetical protein	-
JNN37_RS21490	4467803..4467919	+	117	Protein_4210	VOC family protein	-
JNN37_RS21495	4468164..4469285	+	1122	WP_000010833.1	M42 family metallopeptidase	-
JNN37_RS21500	4469282..4469560	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
JNN37_RS21505	4469572..4470885	+	1314	WP_001519300.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimB	4458244..4466793	8549

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9744.33 Da
• Isoelectric Point: 11.0090

>T187962 WP_001550554.1 NZ_CP068804:4465760-4466017 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKPVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T187962 NZ_CP090146:c2293835-2293350 [Enterobacter hormaechei]
GTGGGACGTGTAACCCCCCCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCATCAGTGGAGAGGCCGTGCTTGA
CGAATGGTTAAAACAAAGAGGTCTGAAAAACCAGGCGCTTGGCGCAGCCCGAACGTTTGTCGTTTGTAAAACGGGCACAA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGGAAGCGACAGGTAATTTGCGGCGTAACATG
CCGGATCCCATTCCCGTGATTATTCTTGCCCGTCTGGCTGTCGATGTCTCAATACGCGGAAATGGGTTGGGAGCCGATTT
ACTCCAGGATGCGGTTTTACGCTGTTATCGGGTAGCAGAGAATATTGGGGTGCGGGCGATCATGGTTCATGCACTCACTG
AGGACGCCAAAGCGTTTTATATCCACCATGGTTTTAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCAGGCTTCCT
CAGTAG

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20463.61 Da
• Isoelectric Point: 6.8758

>AT187962 WP_001519303.1 NZ_CP068804:4466029-4466580 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT187962 NZ_CP090146:c2294089-2293823 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAACTCAATCTTAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGTACTGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAAAATGTGATCCTCGATCGGCGTGTATTCAATT
TTAACGATGAACAGTATGCAGAGTTCATTGATATGCTTGATGCCCCGGTCGCCGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Structures

Toxin

• AlphaFold DB: A0A0V9MKL8