Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3491643..3492261 Replicon chromosome
Accession NZ_CP068803
Organism Escherichia coli strain RIVM_C018404

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag JNN34_RS16835 Protein ID WP_001291435.1
Coordinates 3492043..3492261 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag JNN34_RS16830 Protein ID WP_000344800.1
Coordinates 3491643..3492017 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN34_RS16820 3486732..3487925 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JNN34_RS16825 3487948..3491097 + 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
JNN34_RS16830 3491643..3492017 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
JNN34_RS16835 3492043..3492261 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
JNN34_RS16840 3492432..3492983 + 552 WP_000102564.1 maltose O-acetyltransferase -
JNN34_RS16845 3493099..3493569 + 471 WP_000136192.1 YlaC family protein -
JNN34_RS16850 3493733..3495283 + 1551 WP_202850106.1 EAL domain-containing protein -
JNN34_RS16855 3495325..3495678 - 354 WP_000878140.1 DUF1428 domain-containing protein -
JNN34_RS16865 3496057..3496368 + 312 WP_000409911.1 MGMT family protein -
JNN34_RS16870 3496399..3496971 - 573 WP_000779826.1 lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T187931 WP_001291435.1 NZ_CP068803:3492043-3492261 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T187931 NZ_CP090133:1967198-1967301 [Salmonella enterica subsp. enterica serovar Goldcoast]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT187931 WP_000344800.1 NZ_CP068803:3491643-3492017 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT187931 NZ_CP090133:c1967303-1967160 [Salmonella enterica subsp. enterica serovar Goldcoast]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References