Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 669588..671176 Replicon chromosome
Accession NZ_CP068802
Organism Escherichia coli strain RIVM_C018249

Toxin (Protein)


Gene name hipA Uniprot ID A0A377LF41
Locus tag JNN40_RS03400 Protein ID WP_001125419.1
Coordinates 669854..671176 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A366Y5V8
Locus tag JNN40_RS03395 Protein ID WP_001366357.1
Coordinates 669588..669854 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN40_RS03395 669588..669854 + 267 WP_001366357.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JNN40_RS03400 669854..671176 + 1323 WP_001125419.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
JNN40_RS03405 671327..672226 - 900 WP_001057775.1 LysR family transcriptional regulator -
JNN40_RS03410 672366..672674 + 309 WP_001221046.1 hypothetical protein -
JNN40_RS03415 672683..673372 + 690 WP_000801313.1 type 1 glutamine amidotransferase domain-containing protein -
JNN40_RS03420 673446..674393 + 948 WP_000854795.1 aldo/keto reductase -
JNN40_RS03425 674496..674651 + 156 WP_001327998.1 hypothetical protein -
JNN40_RS03430 674611..675030 + 420 WP_001327999.1 amidohydrolase family protein -
JNN40_RS03435 674981..675172 + 192 WP_001469139.1 amidohydrolase family protein -
JNN40_RS03440 675323..675895 + 573 WP_000789913.1 NAD(P)H-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49317.90 Da        Isoelectric Point: 8.8783

>T187899 WP_001125419.1 NZ_CP068802:669854-671176 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLANRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEQLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPNAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALRDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGSK

Download         Length: 1323 bp

>T187899 NZ_CP090096:c1213830-1213315 [Neorhizobium galegae]
ATGCCTGAATTGGCCTCTGAATCGGGCATCCTCTGGCGTGCCTATGTGCCGCGCTGGGCGCATGCGCCGCTTTCCGGGGA
CGGCGCTGCCCGTTTCGGCGGCCGCTGGAACCCGGTCGGCGCAGCGACCATCTATGCGGCGCGCGAGCTTTCCACCGCCT
GGGCGGAGTACAATCAGGGTTTCGTACAGCACCCGGCGTTGATCGCGCAGCTTCGGCTCGACGGCGCGCGGCTCGCCGAT
CTGACCAACCCCGAGGTTCTGGTTGGTCTTGGTGTCGACGAGACCATCCACCGCTGCGAATGGCGGGCCGATCTCGATGC
CGGCCGGATACCATCGACGCATCTCCTCGCAGAAAGGCTGCTCCATGATGGCTGCGACGGCCTTATCTATCCGTCCTTCA
TGTCGCCGGGCGGAACCTGCGTTACCCTCTGGCGCTGGAACGGCAAGGACCAGCCGAAGCTCACGGTCACGGACCCCGAC
GGTCGGTTGCCCAAAAGCCCAGCATCCTGGTTATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10077.48 Da        Isoelectric Point: 4.9632

>AT187899 WP_001366357.1 NZ_CP068802:669588-669854 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLMTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Download         Length: 267 bp

>AT187899 NZ_CP090096:c1214191-1213823 [Neorhizobium galegae]
ATGGCTCATGTTTTTGAAATCGGCGCCGCCGCTTTCCGTGAACCCCAGTCCGCGCTTCTATCGGCGCGGCGGGTGTCCAA
TCTTCTCGGCCTGACGCATGCGGAACTGGCAAAACTGATCGGTGTCGCCCGCAACACGCTGACGGCCAAAAGCGGCGCCC
GCAAGGTCGATCTGGCGCTCTCCCCGGTCGTCCGCATCCTGGCGATGGCGAGCGAGATGGCCGGCGACGAGAACCGCGCG
GCGATCTGGTTCAAGCACCAGCCTATCCCCGGCTGGGCCGGCAAGACGGCTTACGACCTCGTCGGCGAGGGCAAGGCCGA
CAAGGTACTCGCTTATCTGGAGGCGGTGCGCTCCGGCGTTTATGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A377LF41

Antitoxin

Source ID Structure
AlphaFold DB A0A366Y5V8

References