Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4666152..4666747 Replicon chromosome
Accession NZ_CP068801
Organism Escherichia coli strain RIVM_C018220

Toxin (Protein)


Gene name chpB Uniprot ID A0A0V9NWK6
Locus tag JNN52_RS22725 Protein ID WP_019842229.1
Coordinates 4666152..4666502 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag JNN52_RS22730 Protein ID WP_001223213.1
Coordinates 4666496..4666747 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN52_RS22705 4661482..4662504 - 1023 WP_001550507.1 ABC transporter permease -
JNN52_RS22710 4662518..4664020 - 1503 WP_001550506.1 sugar ABC transporter ATP-binding protein -
JNN52_RS22715 4664152..4665108 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
JNN52_RS22720 4665418..4665948 + 531 WP_000055075.1 inorganic diphosphatase -
JNN52_RS22725 4666152..4666502 - 351 WP_019842229.1 endoribonuclease toxin ChpB Toxin
JNN52_RS22730 4666496..4666747 - 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
JNN52_RS22735 4666959..4667300 - 342 WP_001550504.1 gamma-glutamylcyclotransferase -
JNN52_RS22740 4667303..4671082 - 3780 WP_001550503.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-115)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12483.44 Da        Isoelectric Point: 5.6097

>T187886 WP_019842229.1 NZ_CP068801:c4666502-4666152 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVWMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

>T187886 NZ_CP090095:c914419-913961 [Neorhizobium galegae]
GTGATCGGCTGGCTGCTGGATACCAATGTCGTCGCCGCGCTGATCAATCCGAACGGAGCACCCTCCGTCAAACGGTGGGC
TGCCGGACAGGATGAAGACCGTTTCTTCATCAGCATCCTGACCCTGGCGGAATACGACAAGGGCATCGAGAACCTGCCAG
CGGATGACGAAAATCGCTATCGTTATGCCGCAGCCCGTGATGCGCTCGAGGACAGATTTGCCGGGCGGACCCTTTCCGTC
AGCGACGCGATCGTCAGGCGGTGGGGCGCTATATCCGGGAGGGTGAAGCAGGCGACCAGCCATGCGCCACCGGTGATCGA
TACGCTGTTTGCCGCGACGGCAATCGAGCATAATCTCTATCTCGCCACCCGCAACGTGAAAGACACTCGCGCGTCGGGCG
CGGCAATCTTCGATCCTTGGCAGGACGACCCCGAGCGGTTTCCGCTGAGCCGCCGCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT187886 WP_001223213.1 NZ_CP068801:c4666747-4666496 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT187886 NZ_CP090095:c914688-914416 [Neorhizobium galegae]
ATGCCGGGCAAGCCCACCGCTCACGACAATAGCTGGAAGCTGGAGGATGCCAAGGCACGCTTCAGCGAAGTGGTGAGGCG
CGCGCATAGCGAAGGCCCCCAGCGCGTGACCGTGCGGGGTCGCGACAGCGTCGTCGTGATCAGCACGGAGGAGCTGGAGA
GGCTGACGAGGGCCGCACCTAAGAAATCCTTCGTGGAATTCATGGAAGGCCTGGGGCTGGACACGCTGGAGCTGGAGCGG
GAAGCGGATCGCGGCCGGGATATCGACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V9NWK6

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References