Detailed information of TA system TA187884

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4547333..4548153
• Replicon: chromosome
• Accession: NZ_CP068801
• Organism: Escherichia coli strain RIVM_C018220

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: A0A0V9MKL8
• Locus tag: JNN52_RS22130
• Protein ID: WP_001550554.1
• Coordinates: 4547333..4547590 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: JNN52_RS22135
• Protein ID: WP_001519303.1
• Coordinates: 4547602..4548153 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JNN52_RS22110	4542619..4543725	+	1107	WP_001519308.1	N-acetylneuraminate epimerase	-
JNN52_RS22115	4543790..4544770	+	981	WP_001519307.1	transposase	-
JNN52_RS22120	4545353..4546594	-	1242	Protein_4333	helicase YjhR	-
JNN52_RS22125	4546657..4546956	+	300	WP_001519304.1	GNAT family N-acetyltransferase	-
JNN52_RS22130	4547333..4547590	+	258	WP_001550554.1	hypothetical protein	Toxin
JNN52_RS22135	4547602..4548153	+	552	WP_001519303.1	N-acetyltransferase	Antitoxin
JNN52_RS22140	4548205..4548366	+	162	WP_001519302.1	hypothetical protein	-
JNN52_RS22145	4548403..4548951	+	549	WP_001519301.1	hypothetical protein	-
JNN52_RS22150	4549078..4549338	+	261	WP_000084876.1	hypothetical protein	-
JNN52_RS22155	4549376..4549492	+	117	Protein_4340	VOC family protein	-
JNN52_RS22160	4549737..4550858	+	1122	WP_000010833.1	M42 family metallopeptidase	-
JNN52_RS22165	4550855..4551133	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
JNN52_RS22170	4551145..4552458	+	1314	WP_001519300.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9744.33 Da
• Isoelectric Point: 11.0090

>T187884 WP_001550554.1 NZ_CP068801:4547333-4547590 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKPVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T187884 NZ_CP090094:398207-398497 [Rhizobium leguminosarum]
ATGACAGGCATCATATTTTCTCCTGCTGCGCAAACCGATATTGACAAGATTTGGGATTACACGGCGACGAGTTGGAATGT
CGATCAGGCAGAGCGTTACATCCAGGACATAAGAGACGCTTGCCACGAATTGGCGGAGGGAAGACGGATGAGCCGTCCCT
CAGATATTCGGAAAGGGTACAGAAAGGTCTCTGTTGGCTCTCATTTTCTGTATTTCAAAAGCAATGATGCAGGCCAGATC
ATCATCGTGCGCATCCTTCATCGAAGAATGGACGTAGCCAAGCACCTGTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20463.61 Da
• Isoelectric Point: 6.8758

>AT187884 WP_001519303.1 NZ_CP068801:4547602-4548153 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT187884 NZ_CP090094:397962-398210 [Rhizobium leguminosarum]
ATGGCCAGAAATACGTCCATATCGCTCGGCGAGCATTTCACCAGCTTCATCGATACGCAAGTTCAGGCTGGCCGCTATGG
TTCAGCCACTGACGTTGTTCGGGCCGGCCTTCGCCTACTTGAAGAACACGAAGCCAAAGTGAAGGCATTACAGGATGCCT
TGATTGAAGGCGAGGAATCCGGCCCTGCCACGCCCTTTGATTTCGATGCGTTCAACGCTCGCAAACGTGCGGCGTTCGAG
GCGAAATGA

Structures

Toxin

• AlphaFold DB: A0A0V9MKL8