Detailed information of TA system TA187881

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4075133..4076822
• Replicon: chromosome
• Accession: NZ_CP068801
• Organism: Escherichia coli strain RIVM_C018220

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: V0Z9M0
• Locus tag: JNN52_RS19740
• Protein ID: WP_000365809.1
• Coordinates: 4075133..4076053 (-)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: JNN52_RS19745
• Protein ID: WP_001550661.1
• Coordinates: 4076040..4076822 (-)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JNN52_RS19725	4071223..4072350	-	1128	WP_001550663.1	MFS transporter	-
JNN52_RS19730	4072492..4073550	-	1059	WP_122987197.1	alpha/beta hydrolase	-
JNN52_RS19735	4073815..4074699	+	885	WP_001119037.1	LysR family transcriptional regulator	-
JNN52_RS19740	4075133..4076053	-	921	WP_000365809.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
JNN52_RS19745	4076040..4076822	-	783	WP_001550661.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
JNN52_RS19750	4077138..4080347	+	3210	WP_001521910.1	RNA-directed DNA polymerase	-
JNN52_RS19755	4080508..4080648	+	141	WP_001308408.1	ash family protein	-
JNN52_RS19760	4080694..4081164	+	471	WP_000201185.1	hypothetical protein	-
JNN52_RS19765	4081161..4081263	+	103	Protein_3873	helix-turn-helix domain-containing protein	-
JNN52_RS19770	4081355..4081513	+	159	Protein_3874	integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-261)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (95-247)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34571.01 Da
• Isoelectric Point: 7.2649

>T187881 WP_000365809.1 NZ_CP068801:c4076053-4075133 [Escherichia coli]
MDLRDSYARQVKLLMAALPYVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLEKPGLMREIFDGFLCYLAGHPRPIAELLAPNWDTERIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHLTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAVLKDKNPAKYVAAVNKLERVLA

Nucleotide

• Length: 921 bp

>T187881 NZ_CP090093:c533109-532684 [Rhizobium leguminosarum]
ATGATCCTGATCGATACCAACGTCATCTCAGAGCCATGGAAGCCCACACCCGATAATCAGGTGCTGGCGTGGATCGATGC
CCAAGCAGTGGAAACGCTGTTCGTTTCAGCGATTACAGTAGCTGAGTTACGGTTCGGCATTGCCGCGATGCCTAGCGGAA
GACGAAAGACCGTCCTCTACGATCGACTAGAACAGGAAGTTCTGCCTCTATTTTCAGGACGCGTTCTATCCTTCGACATG
GCTGCGTCACAGAGCTATTCGGAATTAATGGCGCGAGCACGCCTAGCAGGTCGGGCAATCGGTAAAGCAGATGCCTATAT
TGCCGCAATTGCCGCGGCGAACGGATTTATTGTCGCTACCCGCGACACTGGTCCCTTCGAAGCCGCAGGACTTAAGGTTA
TCAACCCTTGGTACGCACCAACATAG

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29191.43 Da
• Isoelectric Point: 8.9059

>AT187881 WP_001550661.1 NZ_CP068801:c4076822-4076040 [Escherichia coli]
MPNYLNWLMQHTLPGQVLLQSWLTRNGIDRKLSYLYVKNGWLRRIAHGVYCRTGREPDWVDAVYCLQSQWEKPVRVAGLT
SLALQGHAHYTEQGKPQVWLALPAYVKLPGWFSAFEQSATFVTLYTSGLTADVTPFTTELKIGDRQLAGSVPELAAYEIA
CGVPSLISFEHADALFQGLNLLSPRKLQALLRASHSVKTNRVMLYLARRNGHPYFQYIDQSGIETGTGKRQIIPGGWLEP
DYQITVPRAFKPEGVEDGSA

Nucleotide

• Length: 783 bp

>AT187881 NZ_CP090093:c533360-533106 [Rhizobium leguminosarum]
ATGGCAGCAGTTACAATACGCAATTTGTCTGAGGAGACACATCGTGCCTTGAGAGTGAGGGCAGCTCATCACGGCCGCAG
TACCGAAGCAGAAATCCGTGACATCCTAGAAACTGCGGTACGGCCAGCTGAGCGCGTGATGTTGGGCTCGTTGCTAGCAT
CAATCGGACGCGAGGCAGGGCTTTCCAACAACGACGTGGATAATCTGCAGCTCGTCCGAGACAAAACGCCTGCGGAACCT
ATGAGTTTCGAATGA

Structures

Toxin

• AlphaFold DB: V0Z9M0